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Table 1 Summary of data to be obtained in the 3H study

From: Effect of haemodiafiltration vs conventional haemodialysis on growth and cardiovascular outcomes in children – the HDF, heart and height (3H) study

Cardiovascular measures (annual intervals) (i) High resolution sonography of the common carotid arteries to measure intima media thickness (morphology, B-Mode) and elasticity (function, M-mode)
(ii) Pulse wave velocity and augmentation index
(iii) Echocardiogram
(iv) 24-h ambulatory blood pressure monitoring
-6-monthly intervals- (i) Weight, height, body mass index and pubertal staging
(ii) Body composition analysis by multifrequency bioelectrical impedance analysis
Biomarker monitoring (6-monthly intervals)
-Nutritional measures Albumin, prealbumin, leptin, ghrelin, cholecystokinin, endogenous growth hormone production (IGF-1, IGF-binding protein), adiponectin, resting energy expenditure (calculated), normalized protein catabolic rate (calculated), physical activity index
-Cardiovascular measures calcium, phosphate, parathyroid hormone, FGF-23 (c-terminal), soluble klotho, 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, β2 microglobulin, fetuin-A, osteoprotegerin, markers of inflammation (IL6, IL-10, high-sensitivity CRP, TNF-α, plasma intradialytic endotoxin), markers of endothelial dysfunction (homocysteine, ADMA, SDMA), markers of bone turnover (bone-specific alkaline phosphatase, sclerostin, collagen telopeptides, β-cross-laps), markers of oxidative and carbonyl stress
Quality of life questionnaires (6-monthly intervals) (i) Paediatric Index of Emotional Distress (Pi-ED)
(ii) Paediatric Quality of Life (PedsQL)
(iii) Strengths Difficulties Questionnaire (SDQ)
(iv) Patient related outcome measures related to dialysis: post-dialysis recovery time, sleep pattern, school attendance, physical activity, appetite.