Table 1 Baseline clinical and pathological characteristics in 74 adults with HSPN
All (n = 74) | |
|---|---|
Clinical parameters | |
Age, years | 47.8 ± 17.4 |
Male/female | 35 (47.3) /39 (52.7) |
Body mass index, kg/m2 | 23.3 ± 4.41 |
Diabetes | 7 (9.5) |
Hypertension | 26 (35.1) |
Systolic blood pressure, mmHg | 125.7 ± 16.9 |
Diastolic blood pressure, mmHg | 74.1 ± 12.2 |
Gross hematuria | 13 (17.6) |
Abdominal symptoms | 25 (33.8) |
Arthralgia | 18 (24.3) |
eGFR, mL/min/1.73 m2 | 76.4 ± 25.8 |
Total cholesterol, mg/dL | 216.4 ± 62.4 |
Serum uric acid, mg/dL | 5.3 [4.1–7.1] |
Serum IgA, mg/dL | 333 [258–453] |
IgA/C3 ratio | 3.01 [2.18–3.76] |
Proteinuria, g/day | 1.40 [0.70–2.38] |
Proteinuria, g/gCr | 1.87 [1.09–3.32] |
U-RBC ≥30/HPF | 38 (51.4) |
Days between purpura onset and renal biopsy | 53 [25–168] |
Pathological parameters | |
Oxford M0/M1 lesion | 69 (93.2)/5 (6.8) |
Oxford E0/E1 lesion | 36(48.6)/38 (51.4) |
Oxford S0/S1 lesion | 36(48.6)/38 (51.4) |
Oxford T0/1/2 lesion | 56 (75.7)/14 (18.9)/4 (5.4) |
Oxford C0/1/2 lesion | 22 (29.7)/35 (47.3)/17 (23.0) |
JHC I/II/III/IV | 39 (52.7)/27 (36.5)/8 (10.8)/0 (0) |
ISKDC grade I/II/III/IV/V | 6 (8.1)/14 (18.9)/52 (70.3)/2 (2.7)/0 (0) |
Treatment | |
RASB | 56 (75.7) |
Days between renal biopsy and steroid therapy | 12 [1–25] |
Oral PSL | 61 (82.4) |
mPSL therapy | 47 (63.5) |