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Fig. 2 | BMC Nephrology

Fig. 2

From: The two isoforms of matrix metalloproteinase- 2 have distinct renal spatial and temporal distributions in murine models of types 1 and 2 diabetes mellitus

Fig. 2

Immunohistochemical staining of kidneys for FL-MMP-2 and NTT-MMP-2 in the STZ model of Type 1 diabetes mellitus. MMP-2 isoform specific IHC was performed as detailed in Methods. Panel I: IHC staining for FL-MMP-2 and NTT-MMP-2 for controls and at 4, 8, 12 and 24 weeks following STZ treatment. There is low basal staining for the FL-MMP-2 isoform in the cortex of control kidneys, while NTT-MMP-2 is not detected. IHC staining for both isoforms progressively increases as a function of time and staining is most prominent in the renal cortex. Panel II: Semi-quantitative scoring of IHC staining. (N = 8 for each group; * p < 0.05; X10))

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