| Placebo | Allopurinol | Enalapril | Acetazolamide | PRM ANOVA/Friedman |
---|---|---|---|---|---|
CrCl (ml/min/1.73Â m2) | 134 [120;148] | 137 [124;150] | 130 [117;142] | 116 [103;130]* | .030 |
Urine output (ml/min) | 1.77 [1.42;2.12] | 1.71 [1.38;2.03] | 1.58 [1.20;1.96] | 1.78 [1.48;2.08] | .411 |
CH2O (ml/min) | −0.32 [−0.62;-0.01] | −0.43 [− 0.68;-0.17] | −0.36 [− 0.71;0.00] | −0.19 [− 0.49;0.10] | .304 |
P-sodium (mmol/l) | 139 [138;139] | 138 [137;139] | 137 [137;138]* | 138 [137;139] | .025 |
U-Na (mmol/24Â h) | 129 [107;151] | 135 [115;154] | 116 [98;134] | 101 [80;122]* | .034 |
FENa (%) | 0.47 [0.40;0.54] | 0.49 [0.39;0.60] | 0.45 [0.38;0.52] | 0.42 [0.35;0.50] | .412 |
P-potassium (mmol/l) | 4.1 [4.0;4.1] | 4.0 [3.9;4.1] | 4.1 [4.0;4.2] | 3.6 [3.6;3.7]* | <.001 |
U-K (mmol/24Â h) | 57.8 (45.9;75.8) | 59.2 (41.3;72.1) | 51.9 (42.5;83.0) | 76.3 (52.7;95.1) | .349 |
FEK (%) | 7.91 [6.71;9.11] | 7.55 [6.17;8.92] | 7.67 [6.48;8.85] | 11.6 [9.84;13.4]* | <.001 |
U-albumin (mg/24Â h) | 2.98 (1.25;4.75) | 2.02 (1.00;4.00) | 4.50 (1.32;8.25)* | 3.00 (2.25;4.75) | .184 |
U-AQP2 (ng/min) | 0.51 (0.41;0.76) | 0.64 (0.46;0.83) | 0.62 (0.42;0.92) | 0.50 (0.38;0.62) | .071 |
U-ENaCγ (ng/min) | 0.23 (0.21;0.31) | 0.28 (0.23;0.34)* | 0.27 (0.23;0.36) | 0.30 (0.24;0.38) | .091 |
P-urate (mmol/l) | 0.29 [0.25;0.33] | 0.16 [0.13;0.20]* | 0.29 [0.25;0.33] | 0.34 [0.30;0.38]* | <.001 |
P-(vB)-total CO2 (mmol/l) | 25.1 [23.9;26.4] | 25.0 [24.0;26.0] | 24.4 [23.7;25.1] | 18.4 [17.4;19.3]* | <.001 |