Skip to main content

Table 2 Effect of allopurinol, enalapril and acetazolamide on 24-h urine collection and selected baseline blood samples

From: The effect of sodium nitrite infusion on renal function, brachial and central blood pressure during enzyme inhibition by allopurinol, enalapril or acetazolamide in healthy subjects: a randomized, double-blinded, placebo-controlled, crossover study

 

Placebo

Allopurinol

Enalapril

Acetazolamide

PRM ANOVA/Friedman

CrCl (ml/min/1.73 m2)

134 [120;148]

137 [124;150]

130 [117;142]

116 [103;130]*

.030

Urine output (ml/min)

1.77 [1.42;2.12]

1.71 [1.38;2.03]

1.58 [1.20;1.96]

1.78 [1.48;2.08]

.411

CH2O (ml/min)

−0.32 [−0.62;-0.01]

−0.43 [− 0.68;-0.17]

−0.36 [− 0.71;0.00]

−0.19 [− 0.49;0.10]

.304

P-sodium (mmol/l)

139 [138;139]

138 [137;139]

137 [137;138]*

138 [137;139]

.025

U-Na (mmol/24 h)

129 [107;151]

135 [115;154]

116 [98;134]

101 [80;122]*

.034

FENa (%)

0.47 [0.40;0.54]

0.49 [0.39;0.60]

0.45 [0.38;0.52]

0.42 [0.35;0.50]

.412

P-potassium (mmol/l)

4.1 [4.0;4.1]

4.0 [3.9;4.1]

4.1 [4.0;4.2]

3.6 [3.6;3.7]*

<.001

U-K (mmol/24 h)

57.8 (45.9;75.8)

59.2 (41.3;72.1)

51.9 (42.5;83.0)

76.3 (52.7;95.1)

.349

FEK (%)

7.91 [6.71;9.11]

7.55 [6.17;8.92]

7.67 [6.48;8.85]

11.6 [9.84;13.4]*

<.001

U-albumin (mg/24 h)

2.98 (1.25;4.75)

2.02 (1.00;4.00)

4.50 (1.32;8.25)*

3.00 (2.25;4.75)

.184

U-AQP2 (ng/min)

0.51 (0.41;0.76)

0.64 (0.46;0.83)

0.62 (0.42;0.92)

0.50 (0.38;0.62)

.071

U-ENaCγ (ng/min)

0.23 (0.21;0.31)

0.28 (0.23;0.34)*

0.27 (0.23;0.36)

0.30 (0.24;0.38)

.091

P-urate (mmol/l)

0.29 [0.25;0.33]

0.16 [0.13;0.20]*

0.29 [0.25;0.33]

0.34 [0.30;0.38]*

<.001

P-(vB)-total CO2 (mmol/l)

25.1 [23.9;26.4]

25.0 [24.0;26.0]

24.4 [23.7;25.1]

18.4 [17.4;19.3]*

<.001

  1. Effect of 4 days treatment with allopurinol, enalapril and acetazolamide on 24-h urine collection and selected baseline blood samples in 16 healthy subjects. Creatinine clearance (CrCl), urine output, free water clearance (CH2O), urinary excretion rate of sodium (U-Na) and potassium (U-K) and fractional excretion of sodium (FENa) and potassium (FEK), urinary excretion rate of albumin, aquaporin-2 (U-AQP2), and γ-subunit of the epithelial sodium channel (U-ENaCγ), plasma sodium (P-Na), potassium (P-K), urate, and total carbon dioxide in venous blood (P-(vB)-total CO2). Normal distributed data are presented as means with 95% confidence interval in brackets, and non-parametric data as medians with 25th and 75th percentiles in parentheses. Statistics were performed using one-way repeated measures (RM) ANOVA or Friedman test (U-albumin, U-AQP2, U-ENaCγ). U-K was log transformed before RM ANOVA. Pairwise comparison with placebo was performed using Student’s t-test or Wilcoxon signed-rank test (U-albumin, U-AQP2, U-ENaCγ)
  2. Statistically significantly different from placebo: * = p < .05