The effect of sodium nitrite infusion on renal function, brachial and central blood pressure during enzyme inhibition by allopurinol, enalapril or acetazolamide in healthy subjects: a randomized, double-blinded, placebo-controlled, crossover study

Table 5 Effect of intravenous NaNO₂ on brachial and central hemodynamics

	Baseline value	Change from baseline to last hour of infusion	p _t-test
Brachial systolic BP (mmHg)
Placebo	115 (111;119)	−2.63 (− 4.41;-0.85)	.007
Allopurinol	115 (111;119)	− 3.07 (−5.12;-1.01)	.006
Enalapril	110 (107;114)^†	−3.84 (−5.32;-2.35)	<.001
Acetazolamide	114 (111;118)	−3.79 (−5.85;-1.74)	.001
p_{RM ANOVA}		.272
Brachial diastolic BP (mmHg)
Placebo	60 (57;62)	−1.50 (−3.28;0.28)	.093
Allopurinol	60 (56;63)	−1.22 (−3.14;0.70)	.196
Enalapril	56 (53;59)^†	−1.18 (−2.40;0.03)	.054
Acetazolamide	60 (58;63)	−1.58 (−3.04;-0.12)	.035
p_{RM ANOVA}		.923
Brachial MAP (mmHg)
Placebo	78 (76;81)	−1.88 (−3.39;-0.37)	.018
Allopurinol	78 (75;81)	−1.84 (−3.63;-0.04)	.046
Enalapril	74 (72;77)^†	−2.07 (−3.28;-0.86.)	.002
Acetazolamide	78 (76;81)	−2.32 (−3.88;-0.76)	.006
p_{RM ANOVA}		.848
Heart rate (beats per minute)
Placebo	55 (52;58)	3.37 (1.95;4.79)	<.001
Allopurinol	55 (52;59)	1.70 (0.12;3.28)^†	.037
Enalapril	56 (52;60)	2.21 (0.97;3.45)	.002
Acetazolamide	57 (53;61)	1.30 (0.11;2.50)^†	.035
p_{RM ANOVA}		.050
Central systolic BP (mmHg)
Placebo	98 (89;106)	−1.38 (−6.03;3.26)	.528
Allopurinol	99 (91;107)	−4.51 (−8.95;-0.07)	.047
Enalapril	97 (88;106)	−4.04 (−8.13;0.05)	.053
Acetazolamide	101 (90;112)	−2.69 (− 8.30;2.91)	.320
p_{RM ANOVA}		.804

Effect of intravenous NaNO₂ on heart rate, brachial and central blood pressure (BP) in 16 healthy subjects after 4 days pretreatment with allopurinol, enalapril, acetazolamide, or placebo. Data are means with 95% confidence interval in brackets. Baseline values are an average of measurements in the one-hour period prior to infusion. The baseline values were compared to an average of measurements during the last hour of NaNO₂ infusion. Pairwise comparisons were performed using Student’s t-test. One-way repeated measures (RM) ANOVA was used for comparison of effects between pretreatments
^†: p < .05 vs. placebo

ISSN: 1471-2369