Table 1 Characteristics of the five patients
From: Use of rituximab as an induction therapy in anti-glomerular basement-membrane disease
At diagnosis | |
|---|---|
Age (median, ranges) | 72 (17 to 96) |
Gender (M/F) | 1/4 |
Comorbidities | |
Hypertension | 2/5 |
Tobacco | 2/5 |
Diabetes mellitus | 0/5 |
Toxic exposure | 0/5 |
Pulmonary symptoms | 3/5 |
Mechanical ventilation required | 1/5 |
Serum creatinine μmol/L (median, ranges) | 605 (47 to 800) |
Dialysis required at diagnosis | 4/5 |
Proteinuria g/L (median, ranges) | 4 (0.2 to 6) |
Biological characteristics | |
Hemoglobin g/L (mean, ranges) | 95 (76 to 116) |
Anti-GBM titer of dilution (IIF) (mean, ranges) | 97 (5 to 640) |
ANCA + | 2/5 |
Crescents > 50% on biopsy | 2/3 |
Treatment | |
Number of plasma-exchange sessions, mean (range) | 16 (9 to 23) |
Corticosteroids | 5/5 |
Rituximab as a first-line treatment | 5/5 |