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Table 1 Reported cases of renal immunoglobulin heavy-chain amyloidosis and amyloid responsible region of immunoglobulin heavy-chain

From: AL amyloidosis with non-amyloid forming monoclonal immunoglobulin deposition; a case mimicking AHL amyloidosis

Age/Gen Method for diagnosis Sample preparation method IEP Immunostaining Detail of amyloid protein Size of amyloid protein Structural abnormality of amyloid protein Reported year Ref
65/F WB/AASA Amyloid purification IgG-κ ND VH + Cγ3 22 kDa VH directly contiguous with CH3 1990 [9]
59/M WB/AASA Amyloid purification IgG-κ K(−), λ(−) vH 11 kDa VH with truncated D segment 1994 [10]
64/M Immunostaining   IgA-κ IgA(+), κ(−), λ(−) NA NA NA 2002 [11]
56/M Immunostaining   IgM-λ IgM(+), κ(−), λ(−) NA NA NA 2003 [12]
53/F Immunostaining   IgG-λ IgG(+), κ(−), λ(+) NA NA NA 2003 [13]
72/F AASA Amyloid purification IgG-λ IgG(−), κ(−), λ(−) vH 11 kDa truncated VH 2004 [14]
61/F AASA Amyloid purification IgG-κ IgG(−), κ(−), λ(−) vH 11 kDa VH with truncated D segment 2006 [15]
67/M LC-MS/MS Amyloid purification IgM-κ K(−), λ(−) vH 11 kDa truncated VH 2008 [16]
50/M LC-MS/MS LMD IgG-λ ND VH + Cγ3 NA NA 2010 [2]
36/M LC-MS/MS LMD IgG-κ IgG(+), IgA(+), IgM(+), κ(+), λ(+) VH + Cγ3 NA NA 2010 [2]
ND LC-MS/MS LMD IgA-λ IgA(+), λ(+) VH + Cα1 NA NA 2013 [3]
ND LC-MS/MS LMD IgG-λ IgG(+), λ(+) 1 NA NA 2013 [3]
ND LC-MS/MS LMD negative IgG(+) 1, Cγ4 NA NA 2013 [3]
ND Immunostaining   IgG-λ IgG1,(+) NA NA NA 2013 [3]
70/F LC-MS/MS Amyloid purification IgG-λ IgG(−), κ(−), λ(−) VH + Cγ1 11 kDa VH with truncated CHI 2015 [17]
  1. IEP immunoelectrophoresis, Ref reference, WB western blotting, AASA amino acid sequence analysis, ND not documented, VH immunoglobulin heavy-chain variable domain, Cγ3 gamma3 heavy-chain constant domain, NA not analyzed, LC-MS/MS liquid chromatography-tandem mass spectrometry, LMD laser micro dissection, alpha heavy-chain constant domain