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Fig. 3 | BMC Nephrology

Fig. 3

From: Long-term survival in Japanese renal transplant recipients with Alport syndrome: a retrospective study

Fig. 3

Immunofluorescence staining of type IV collagen α5 chain. Immunofluorescence staining of type IV collagen α2 chain (red), α5 chain (green), and merged images (combined red and green) of GBM on allograft biopsy specimens of AS recipients performed more than 1 year after transplantation (patient characteristics are shown in Table 3). In all cases, the type IV collagen α5 chain was stained linearly in the GBM without defects. Case1: A 27-year-old woman. Allograft biopsy specimen at 33 months after transplantation. The pathological diagnosis was chronic active antibody-mediated rejection. Case 11: A 21-year-old man. Allograft biopsy specimen at 101 months after transplantation. The pathological diagnosis was arteriolar hyalinosis. Case 12: A 21-year-old man. Allograft biopsy specimen at 110 months after transplantation. The pathological diagnoses were chronic active antibody-mediated rejection and IF/TA, moderate. The immunoreactivity of type IV collagen α2 chain was slightly increased in the mesangial and subendothelial regions compared with that in the other cases. Case 15: A 26-year-old man. Allograft biopsy specimen at 12 months after transplantation. The pathological diagnosis was minimally aggressive tubulointerstitial rejection, mild. Case 16: A 26-year-old man. Allograft biopsy specimen at 12 months after transplantation. The pathological diagnosis was no evidence of rejection. Case 19: A 23-year-old man. Allograft biopsy specimen at 14 months after transplantation. The pathological diagnosis was IF/TA, mild

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