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Table 7 Comparative outcomes of present study with previously published pediatric CRRT studies; FO, fluid overload, EM electrolyte management

From: Pediatric continuous renal replacement therapy: have practice changes changed outcomes? A large single-center ten-year retrospective evaluation

  Our Study ppCRRT Registry a, b Spain c, d Birmingham e Alberta (CRRT only) f
N 273 344 174 76 49
Weight
 Mean/Median Wt (kg) 33.5 34.3   19.5(2.5–150) 19.5 (5.5–45)
 Less than 10 kg (%) 23 24 43   
 10 to 20 kg (%) 25 20    
 20 to 50 kg (%) 25 29    
 > 50 kg (%) 27 27    
Age
 Mean / Median Age (yr) 8.4 8.5 4.3 (±5.3) 5.8 (0–17.8) 5.4 (0.3–13.8)
 0 to 1 yr. (%) 21 20 43.7   
 1 to 3 yr. (%) 12 13    
 3 to 5 yr. (%) 8 8    
 5 to 10 yr. (%) 14 17    
 10 to 15 yr. (%) 21 19    
 15 to 21 yr. (%) 20 20    
 > 21 yr. (%) 4 3    
Survival to discharge (%) 48 58 64 55 67
Principle diagnosis (%)
 Sepsis 5 24 20 12  
 BMT 12 16   16  
 Cardiac 9 12 56 9  
 Renal 10 9 10 20  
 Liver 21 8   6  
 Malignancy 13 8   8  
 Ischemia/shock   6    
 Inborn error of metabolism 5 4 7   
 Drug intoxication   4 2   
 Tumor lysis syndrome   3 3 14  
 Pulmonary 5 3    
 Other 11 2 05 14  
Survival on CRRT by Weight (N (%))
 < 10 kg 28 (43%) 36 (43%) 57%   
 > 10 kg 105 (49%) 165 (63%) 73%   
ICU days before CRRT 4 (1,10) 2    2 (1–5)
Days on CRRT 8 (4,16)     7 (3–18)
% FO 15 (8, 26)    12.9 (0–66.4) 20.1 (5.4–32.5)
Indication for CRRT & survival (%)
 FO and EM 29 (41%) 15 32g   
 FO 67 (45%) 18    
 EM 8(50%) 20 42h   
 Prevent FO /provide nutrition 5(56%) 20    
 Other 24 (55%) 21    
  1. a. Symons JM, Chua AN, Somers MJ, et al. Demographic characteristics of pediatric continuous renal replacement therapy: a report of the prospective pediatric continuous renal replacement therapy registry. Clin J Am Soc Nephrol. July 2007;2(4):732–738
  2. b. Sutherland SM, Zappitelli M, Alexander SR, et al. Fluid overload and mortality in children receiving continuous renal replacement therapy: the prospective pediatric continuous renal replacement therapy registry. Am J Kidney Dis. Feb 2010;55(2):316–25
  3. c. Lopez-Herc J, Santiago MJ, Solana MJ et al. Clinical course of children requiring prolonged continuous renal replacement therapy. Pediatr Nephrol. Dec 2010; 25:523–528
  4. d. Santiago MJ, Lopez-Herce J, Urbando J, et al. Clinical course and mortality risk factors in critically ill children requiring continuous renal replacement therapy. Intensive Care Med. May 2010;36(5):843–9
  5. e. Hayes LW, Oster RA, Tofil NM, et al. Outcomes of critically ill children requiring continuous renal replacement therapy. J Crit Care. Sep 2009;24(3):394–400
  6. f. Boschee E, Cave D, Garros D, et al. Indications and outcomes in children receiving renal replacement therapy in pediatric intensive care. J Crit Care. Feb 2014;29(1):37–42
  7. g. Patients with diagnosis of AKI and hypervolemia
  8. h. Patients with diagnosis of AKI