Serum levels of tumor necrosis factor alpha in patients with IgA nephropathy are closely associated with disease severity

Table 3 Correlation between serum TNF-α and clinical parameters of patients with IgA nephropathy

Variable	Bivariate Regression Coefficient	Bivariate P Value ^a	Multivariate Regression Coefficient	Multivariate P Value ^b
Sex		0.02 ^c
Systolic BP	0.30	< 0.0001
Diastolic BP	0.19	0.02
24-h urine protein excretion	0.22	0.007	0.33	0.04
Urinary protein to serum creatinine ratio	0.26	0.002	0.33	0.03
Serum creatinine	0.49	< 0.0001	0.46	< 0.0001
Cystatin C	0.51	< 0.0001	0.59	< 0.0001
eGFR ^d	−0.47	< 0.0001	0.49	< 0.0001

BP: blood pressure; 1 mmHg = 0.133Kpa; eGFR: estimated glomerular filtration rate
^aSpearman's correlation analysis unless otherwise specified
^bMultiple linear regression adjusted for sex, Systolic BP and Diastolic BP
^cMann–Whitney U-test
^deGFR was calculated according to the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation [19]

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