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Table 2 Glomerular histopathological and histomorphometric variables stratified by LBW and/or SGA, Norway (1988–2013)

From: Low birth weight associates with glomerular area in young male IgA nephropathy patients

 

IgAN Controls Without

IgAN Cases

IgAN cases combined

LBW or SGA

LBW but not SGA

SGA but not LBW

Both LBW and SGA

LBW and/or SGA

N

18

11

10

12

33

N (%) with M-score of 1

10 (55.6)

8 (72.7)

5 (50.0)

4 (33.3)

17 (51.5)

N (%) with E-score of 1

3 (16.7)

2 (18.2)

0 (0.0)

1 (8.3)

3 (9.1)

N (%) with S-score of 1

1 (5.6)

3 (27.3)

2 (20.0)

1 (8.3)

6 (18.2)

N (%) with T-score of 1

0 (0.0)

0 (0.0)

0 (0.0)

0 (0.0)

0 (0.0)

% of glomeruli with mesangial hypercellularity

49.6 ± 27.4

49.1 ± 35.6

39.8 ± 21.7

35.0 ± 29.7

41.2 ± 29.4

% of glomeruli with endocapillary hypercellularity

0.93 ± 2.7

7.3 ± 20.1

0.00 ± 0.00

2.0 ± 6.8

3.2 ± 12.3

% of glomeruli with global sclerosis

3.3 ± 6.9

12.8 ± 29.6

3.3 ± 6.2

2.5 ± 5.9

5.9 ± 17.8

% of glomeruli with segmental sclerosis

0.69 ± 2.9

2.5 ± 5.2

1.6 ± 3.3

0.25 ± 0.85

1.5 ± 3.6

Histomorphometric variables

 Number of glomeruli (N)

14.1 ± 7.8

16.0 ± 7.5

16.2 ± 6.4

14.7 ± 11.4

15.6 ± 8.6

 Glomerular tuft volume (μm3x106) c

2.37 ± 0.82

2.90 ± 0.97

2.81 ± 1.13

2.93 ± 0.89

2.89 ± 0.96

 Glomerular tuft area (μm2)

14,036 ± 3502

16,311 ± 3805

15,899 ± 4335

16,447 ± 3478

16,235 ± 3744a

 Glomerular tuft diameter (μm) c

132.7.4 ± 16.8

143.1. ± 17.5

141.1 ± 19.5

143.9 ± 15.9

142.8 ± 17.0a

 Glomerular density (N per 106 μm2)

2.95 ± 0.85

3.54 ± 1.30

3.36 ± 0.93

2.66 ± 1.47

3.17 ± 1.30

  1. ap-value< 0.01,bp-value< 0.001 as compared to IgAN controls
  2. c Glomerular tuft volume and glomerular tuft diameter was calculated based on the measured glomerular tuft area (as described in detail in the methods section)