From: Low birth weight associates with glomerular area in young male IgA nephropathy patients
IgAN Controls Without | IgAN Cases | IgAN cases combined | |||
---|---|---|---|---|---|
LBW or SGA | LBW but not SGA | SGA but not LBW | Both LBW and SGA | LBW and/or SGA | |
N | 18 | 11 | 10 | 12 | 33 |
N (%) with M-score of 1 | 10 (55.6) | 8 (72.7) | 5 (50.0) | 4 (33.3) | 17 (51.5) |
N (%) with E-score of 1 | 3 (16.7) | 2 (18.2) | 0 (0.0) | 1 (8.3) | 3 (9.1) |
N (%) with S-score of 1 | 1 (5.6) | 3 (27.3) | 2 (20.0) | 1 (8.3) | 6 (18.2) |
N (%) with T-score of 1 | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
% of glomeruli with mesangial hypercellularity | 49.6 ± 27.4 | 49.1 ± 35.6 | 39.8 ± 21.7 | 35.0 ± 29.7 | 41.2 ± 29.4 |
% of glomeruli with endocapillary hypercellularity | 0.93 ± 2.7 | 7.3 ± 20.1 | 0.00 ± 0.00 | 2.0 ± 6.8 | 3.2 ± 12.3 |
% of glomeruli with global sclerosis | 3.3 ± 6.9 | 12.8 ± 29.6 | 3.3 ± 6.2 | 2.5 ± 5.9 | 5.9 ± 17.8 |
% of glomeruli with segmental sclerosis | 0.69 ± 2.9 | 2.5 ± 5.2 | 1.6 ± 3.3 | 0.25 ± 0.85 | 1.5 ± 3.6 |
Histomorphometric variables | |||||
Number of glomeruli (N) | 14.1 ± 7.8 | 16.0 ± 7.5 | 16.2 ± 6.4 | 14.7 ± 11.4 | 15.6 ± 8.6 |
Glomerular tuft volume (μm3x106) c | 2.37 ± 0.82 | 2.90 ± 0.97 | 2.81 ± 1.13 | 2.93 ± 0.89 | 2.89 ± 0.96 |
Glomerular tuft area (μm2) | 14,036 ± 3502 | 16,311 ± 3805 | 15,899 ± 4335 | 16,447 ± 3478 | 16,235 ± 3744a |
Glomerular tuft diameter (μm) c | 132.7.4 ± 16.8 | 143.1. ± 17.5 | 141.1 ± 19.5 | 143.9 ± 15.9 | 142.8 ± 17.0a |
Glomerular density (N per 106 μm2) | 2.95 ± 0.85 | 3.54 ± 1.30 | 3.36 ± 0.93 | 2.66 ± 1.47 | 3.17 ± 1.30 |