Table 2 Univariate and multivariate analysis of factors predictive of outcomes
AKI | Mortality | |||||||
|---|---|---|---|---|---|---|---|---|
Unadjusted OR (95% CI) | P-value | Adjusted OR (95% CI) | P-value | Unadjusted OR (95% CI) | P-value | Adjusted OR (95% CI) | P-value | |
Preoperative characteristics | ||||||||
Age | 1.05 (1.04–1.07) | < 0.0001 | 1.04 (1.0 2-1.06) | < 0.0001 | 1.1 (1.06–1.2) | < 0.0001 | 1.10 (1.03–1.17) | 0.003 |
Male | 1.5 (0.9–2.4) | 0.07 | 1.1 (0.5–2.2) | 0.887 | ||||
Caucasian | 0.8 (0.3–2.3) | 0.680 | 1.3 (1.2–9.7) | 0.831 | ||||
Diabetes | 0.046 (0.01–0.15) | 0.363 | 0.01 (0.01–0.05) | 0.839 | ||||
CVD | 0.35 (0.2–0.5) | < 0.0001 | 0.23 (0.089–0.38) | 0.002 | 0.115 (0.023–0.21) | 0.14 | ||
COPD | 0.31 (0. 15-0.48) | < 0.0001 | 0.22 (0.07–0.37) | 0.005 | 0.059 (0.001–0.158) | 0.245 | ||
Solid malignancy | 1.9 (1. 2-2.9) | 0.005 | 1.47 (0.85–2.54) | 0.174 | 1.5 (0. 7-3.2) | 0.287 | ||
ASA physical status IV/V | 2.5 (1. 2-4.9) | 0.01 | 1.16 (0.49–2.78) | 0.732 | 15.4 (6. 7-35.6) | < 0.0001 | 10.71 (2.90–39.54) | < 0.0001 |
Hemoglobin (g/dL) | 0.8 (0. 7-0.9) | < 0.0001 | 0.97 (0.82–1.14) | 0.675 | 0.63 (0. 5-0.8) | < 0.0001 | 0.73 (0.51–1.04) | 0.077 |
Baseline SCr (mg/dL) | 2.3 (1. 5-3.4) | < 0.0001 | 1.28 (0.78–2.12) | 0.327 | 2.3 (1. 3-3.9) | 0.003 | 0.56 (0. 24-1.30) | 0.174 |
Preoperative sepsis | 3.52 (2.06–6.03) | < 0.0001 | 1.30 (0.63–2.66) | 0.480 | 19.9 (8. 37-47.43) | < 0.0001 | 5.23 (1.46–18.75) | 0.011 |
Urgency surgery | 0.3 (0. 8-2.1) | 0.368 | 4.2 (1. 9-8.9) | < 0.0001 | 1.32 (0. 33-5.22) | 0.693 | ||
Intraoperative characteristics | ||||||||
Duration of anesthesia | 1.02 (1-1.05)0.024 | 0.024 | 1.00 (1.00–1.00) | 0.156 | 1.00 (0.997–1.004) | 0.845 | ||
Hypotension episodes | 1.2 (1. 1-1.4) | 0.001 | 1.10 (0.95–1.26) | 0.203 | 1.46 (1. 27-1.69) | < 0.0001 | 1.52 (1. 16-1.98) | 0.002 |
Crystalloids with colloids | 3 (1. 8-5) | < 0.0001 | 1.80 (0.97–3.33) | 0.062 | 6.05 (1.80–20.29) | 0.004 | 2.61 (0.43–15.68) | 0.296 |
Fluid balance | 1.00 (1.00–1.001) | 0.048 | 1.00 (1.00–1.001) | < 0.0001 | ||||
Erythrocytes (per unit) | 3.7 (2. 4-5.8) | < 0.0001 | 2.27 (1.45–3.55) | < 0.0001 | 2.25 (1.49–3.40) | < 0.0001 | 1.22 (0.68–2.20) | 0.508 |
Vasoactive drugs use | 1.8 (1. 1-3) | 0.039 | 1.10 (0.58–2.11) | 0.769 | 5.87 (2.70–12.74) | < 0.0001 | 4.08 (1. 21-13.78) | 0.023 |
Post-operative characteristics | ||||||||
NL/P (per point increase) | 1.1 (1.04–1.16) | 0.001 | 1.05 (1.00–1.10) | 0.048 | 1.04 (0.995–1.106) | 0.078 | 0.95 (0.84–1.08) | 0.463 |
NL/P > 4.86 | 2.4 (1.53–3.77) | < 0.0001 | 1.72 (1.04–2.87) | 0.036 | 2.56 (1. 19-5.5) | 0.178 | 1.16 (0. 38-3.5) | 0.798 |
AKI | 11.19 (4.78–27.18) | < 0.0001 | 3.56 (1.02–12.43) | 0.046 | ||||