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Table 4 Comparison of clinical parameters between UMOD positive and negative patients with non-polycystic genetic kidney diseases

From: Autosomal dominant tubulointerstitial kidney disease-UMOD is the most frequent non polycystic genetic kidney disease

Clinical parameter

UMOD positive

UMOD negative

Significance level (p < 0.0036)

Age at presentation [years]

9–57, median 39, n = 21

0–80, median 35, n = 66

p = 0.882*

Age at RRT [years]

27–66, median 47, n = 27

9–84, median 41, n = 61

p = 0.116*

Gout

15/33 patients (45%)

30/78 (38%)

p = 0.493**

Allopurinol use

13/35 patients (37%)

22/78 (28%)

p = 0.342**

Hypertension at presentation

31/35 patients (89%)

69/78 (88%)

p = 1.0***

Hyperuricaemia (Uric acid > 0.35 umol/l)

24/26 patients (92%)

50/61 patients (82%)

p = 0.328***

Uric Acid [umol/l]

0.28–0.79, median 0.45, n = 25

0.12–0.85, median 0.495, n = 60

p = 0.155*

Proteinuria

8/22 patients (36%)

48/62 patients (77%)

p = 0.0004**

Protein Creatinine Ratio [mg/g]

0–2761, median 234.5, n = 18

53–20,398, median = 2150, n = 52

p < 0.001*

Anaemia pre RRT (Hb < 100 g/l)

4/27 patients (15%)

25/68 patients (37%)

p = 0.036**

Microscopic haematuria

1/27 patients (4%)

24/63 patients (38%)

p = 0.001**

Renal cysts

4/21 patients (19%)

6/51 patients (12%)

p = 0.463***

Normal renal size at presentation (renal diameter > 9 cm)

11/23 patients (48%)

30/48 patients (63%)

p = 0.241**

Electrolyte abnormalities

6/32 patients (19%)

2/67 patients (3%)

p = 0.013***

  1. A Bonferroni correction was employed to adjust the significance level for the number of performed tests (i.e. the adjusted significance level is p < 0.05/14)
  2. * = Mann Whitney U, ** = χ2, *** = Fisher’s Exact test