Table 5 Comparison of clinical parameters between UMOD positive and negative patients with ADTKD

Age at presentation [years]

9–57, median 39, n = 21

23–80, median 49, n = 20

p = 0.024*

Age at RRT [years]

27–66, median 47, n = 27

27–83, median 51.5, n = 16

p = 0.606*

Gout

15/33 patients (45%)

10/25 patients (40%)

p = 0.678**

Allopurinol use

13/35 patients (37%)

6/25 patients (24%)

p = 0.281**

Hypertension at presentation

31/35 patients (89%)

22/25 patients (88%)

p = 1.0***

Hyperuricaemia (Uric acid > 0.35 umol/l)

24/26 patients (92%)

15/19 patients (79%)

p = 0.377***

Uric Acid [mg/dl]

4.71–13.28, median 7.75, n = 25

4.54–12.27, median 8.07, n = 19

p = 0.61*

Proteinuria

8/22 patients (36%)

6/17 patients (35%)

p = 0.945**

Protein Creatinine Ratio [mg/g]

0–2761, median 234.5, n = 18

53–2469, median 624, n = 14

p = 0.065*

Anaemia pre RRT (Hb < 100 g/l)

4/27 patients (15%)

7/22 patients (32%)

p = 0.185***

Microscopic haematuria

1/27 patients (4%)

1/19 patients (5%)

p = 1.0***

Renal cysts

4/21 patients (19%)

4/15 patients (27%)

p = 0.694***

Normal renal size at presentation (renal diameter > 9 cm)

11/23 patients (48%)

12/19 patients (63%)

p = 0.32**

Electrolyte abnormalities

6/32 patients (19%)

1/22 patients (5%)

p = 0.22***