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Table 3 Crude mortality rate and multivariate adjusted hazard ratio for mortality according to the different dosage categories of oral activated vitamin D based on trajectory analysis

From: Assessing the effect of oral activated vitamin D on overall survival in hemodialysis patients: a landmark analysis

 

N (%)

Follow-up (person-years)

Death (%)

Crude mortality rate (per 100 person-year)

Adjusted HRb

(95% CI)

Non-users

45,386 (86.0)

145,396.7

18,853 (41.5)

12.97

Reference

Conventional dose vitamin D

6849 (13.0)

24,398.0

2112 (30.8)

8.66

0.88 (0.84–0.92)

High dose vitamin D usersa

522 (1.0)

2312.6

136 (26.1)

5.88

0.66 (0.55–0.78)

Overall

52,757 (100)

172,107.3

21,101 (40.0)

12.26

 
  1. Abbreviations: HR hazard ratio, CI confidence intervals
  2. aThe high dose vitamin D users consisted of the upper 99th percentile of dosage prescriptions (n = 196) that were previously excluded from trajectory analysis plus the minority of higher dose vitamin D users (n = 326) in the trajectory analysis
  3. bThe Cox model was adjusted by covariates including age, sex, vascular access type, baseline comorbidities, and medications