Table 4 Renal pathology at biopsy in adults with IgAV-related nephritis
Control (n = 257) | Group 1 (n = 381) | Group 2 (n = 60) | P | |
|---|---|---|---|---|
Light microscopy | ||||
Crescents, % | 0a,b | 8.3 (5.0–14.3)c | 35.6 (29.6–42.0) | P < 0.001** |
Glomeruli-bowman’s capsule adhesion, n (%) | 92 (35.8) | 206 (54.1) | 33 (55.0) | P < 0.001** |
Capillary necrosis, n (%) | 29 (11.3) | 105 (27.6) | 32 (53.3) | P < 0.001** |
Glomerular sclerosis, % | 6.3 (0–15.8) | 4.5 (0–11.8) | 4.9 (0–13.1) | P = 0.261 |
Segmental sclerosis, % | 0 (0–7.4)b | 0 (0–7.4)c | 0 (0–5.1) | P = 0.101 |
Tubular atrophy/ interstitial fibrosis | ||||
None (0), n (%) | 139 (54.1) | 230 (60.4) | 30 (50.0) | P = 0.183 |
Mild (1), n (%) | 92 (35.8) | 106 (27.8) | 19 (31.7) | |
Moderate (2), n (%) | 25 (9.7) | 42 (11.0) | 11 (18.3) | |
Severe (3), n (%) | 1 (0.4) | 3 (0.8) | 0 (0) | |
Immunofluorescence | ||||
IgG, n (%) | 41 (16.0) | 63 (16.5) | 5 (8.3) | P = 0.262 |
IgM, n (%) | 93 (36.2) | 139 (36.5) | 20 (33.3) | P = 0.894 |
C3, n (%) | 220 (85.6) | 331 (86.9) | 56 (93.3) | P = 0.277 |
C1q, n (%) | 6 (2.3) | 7 (1.8) | 3 (5.0) | P = 0.314 |
IgA and IgG and C3, n (%) | 40 (15.6) | 61 (16.0) | 5 (8.3) | P = 0.299 |