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Table 5 Association between M-, T- and C- scores and clinical outcome in the two treatment arms of the STOP-IgAN trial (available cases analysis)

From: Renal outcomes of STOP-IgAN trial patients in relation to baseline histology (MEST-C scores)

  

M0 events/ total

M1 events/ total

T0 events/ total

T1/2 events/ total

C0 events/ total

C1/2 events/ total

Full clinical remissiona

SUPc

2/22 (9%)

0/8 (0%)

2/15 (13%)

0/15 (0%)

1/23 (4%)

1/7 (14%)

IMMd

6/26 (23%)

0/9 (0%)

4/24 (17%)

2/11 (18%)

3/22 (14%)

3/13 (23%)

GFR-loss ≥15 ml/min

SUP

7/24 (29%)

4/8 (50%)

4/15 (27%)

7/17 (41%)

6/24 (25%)

5/8 (63%)

IMM

7/27 (26%)

5/10 (50%)

7/25 (28%)

5/12 (42%)

10/23 (43%)

2/14 (15%)

ESRDb

SUP

3/24 (13%)

1/8 (13%)

1/15 (7%)

3/17 (18%)

1/24 (4%)

3/8 (38%)

IMM

4/27 (15%)

0/10 (0%)

0/25 (0%)

4/12 (33%)

3/23 (13%)

1/14 (7%)

  1. aurinary protein-creatinine ratio < 0.2 g/g and an eGFR decrease of < 5 ml/min/1.73m2
  2. bend-stage renal disease
  3. cpatients under supportive treatment during the 3-year trial phase
  4. dpatients under additional immunosuppression during the 3-year trial phase