Table 3 MCNS treatment and outcome
Patient | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 |
|---|---|---|---|---|---|---|---|---|
First-line treatment | Steroids | Steroids | Spontaneous remission | Steroids | Steroids | Spontaneous remission | Steroids | Steroids |
CR | Y | Y | Y | Y | Y | N | NA | Y |
PR | – | – | – | – | – | Y | NA | – |
Steroid-dependence (dose of steroid at the time of relapse) | N | Y (10Â mg/d) | N | Y (5Â mg/d) | Y (5Â mg/d) | N | NA | N |
Steroid resistance | N | N | N | N | N | N | NA | N |
Number of relapses during follow-up | 1 | 2 | 3 | 2 | > 6 | 0 | NA | 0 |
Time between MCNS diagnosis and first relapse (months) | 9 | 3 | 11 | 1 | 8 | – | – | – |
Second line treatment | Steroids | Steroids + Rituximab | Steroids + Rituximab | Steroids + Rituximab | Steroids + CsA + MMF + Rituximab | – | – | – |
Follow-up (months) | 13 | 20 | 68 | 14 | 111 | 9 | NC | 91 |
Status at last follow-up visit | CR | PR | CR | CR | CR | PR | NA | CR |
Proteinuria (g/24Â h) at last follow-up visit | 0.1 | 1.25 | 0.12 | 0.1 | 0.28 | 0.89 | NA | 0.1 |
Serum albumine (g/L) at last follow-up visit | 36.2 | 37.2 | 40 | 37 | 31 | 43 | NA | 40 |
Serum creatinine (μmol/l) at last-follow-up visit | 78 | 95 | 138 | 64 | 66 | 71 | NA | 109 |
eGFR CKD-EPI (ml/min/1.73m2) at last follow-up visit | 99 | 73 | 39 | 104 | 120 | 99 | NA | 108 |