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Fig. 2 | BMC Nephrology

Fig. 2

From: Maternally inherited diabetes and deafness complicated by mesangial galactose-deficient IgA1 deposits: a case report

Fig. 2

Light microscopy findings of the repeat renal biopsies. a-c show specimens from the first biopsy in 2009, and df depict those from the second biopsy in 2015. a Mesangial widening. b No evidence of either globally sclerosed glomeruli or tubular damage. c Granular swollen epithelial cells (GSECs; arrowheads) were widely distributed among the tubules and collecting ducts. d Minor glomerular abnormalities. e A total of 24% of glomeruli are replaced by globally sclerosed glomeruli with moderate tubular atrophy and interstitial fibrosis. f Abnormally distended epithelial cell (arrowhead) containing numerous small intracytoplasmic periodic acid-Schiff stain (PAS)-positive granules among the collecting ducts; these are identical to GSECs. a and d shown at magnification × 400, methenamine silver stain; b and e shown at magnification × 100, trichrome stain; c and f shown at magnification × 200, trichrome stain GSECs, granular swollen epithelial cells; PAS, periodic acid-Schiff stain

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