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Table 2 Hazard ratios (HR) for incident chronic kidney disease by HBsAg serology (nā€‰=ā€‰299,913)

From: Hepatitis B virus infection and development of chronic kidney disease: a cohort study

Ā 

No. of incident cases

(person-years)

Model 1

HR

(95% CI)

Model 2

HR

(95% CI)

Model 3

HR

(95% CI)

eGFRā€‰<ā€‰60ā€‰ml/min/1.73m2 or proteinuria

Ā Ā Ā Ā 

HBsAg (āˆ’)

13,315

(1,608,299.2)

1.00

(reference)

1.00

(reference)

1.00

(reference)

HBsAg (+)

609

(65,401.8)

1.07

(0.99ā€“1.16)

1.09

(1.00ā€“1.18)

1.11

(1.03ā€“1.21)

eGFRā€‰<ā€‰60ā€‰ml/min/1.73m2

Ā Ā Ā Ā 

HBsAg (āˆ’)

3106

(1,641,700.4)

1.00

(reference)

1.00

(reference)

1.00

(reference)

HBsAg (+)

119

(67,044.5)

0.91

(0.76ā€“1.09)

0.87

(0.72ā€“1.05)

0.89

(0.73ā€“1.07)

Proteinuria

Ā Ā Ā Ā 

HBsAg (āˆ’)

10,560

(1,621,635.3)

1.00

(reference)

1.00

(reference)

1.00

(reference)

HBsAg (+)

512

(65,806.8)

1.17

(1.07ā€“1.28)

1.20

(1.10ā€“1.31)

1.23

(1.12ā€“1.35)

  1. Model 1: adjusted for age, sex, center, and baseline eGFR; Model 2: further adjusted for smoking (never, former and current), alcohol intake (g/day), level of education (high school graduate or less and college graduate or higher), physical activity (moderate- or vigorous-intensity physical activity <ā€‰3 times/week andā€‰ā‰„ā€‰3 times/week), and BMI (kg/m2); and Model 3: further adjusted for hypertension, diabetes, and presence of fatty liver disease