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Fig. 2 | BMC Nephrology

Fig. 2

From: A novel model of reno-cardiac syndrome in the C57BL/ 6 mouse strain

Fig. 2

Cardiac expression of phospho –Akt, caspase 3, fibronectin and α-SMA. Control group (n = 6) received standard chow for 20 weeks. Adenine treated group (n = 10) received standard chow with the addition of 0.15% adenine for 20 weeks. Representational Western blots (n = 3). Compared with mice on a normal diet, adenine fed mice had a significantly higher degree of cardiac phosphorylation of AKT on Ser473 (a) (P < 0.05), significantly increased expression of caspase 3 (b) (P < 0.05), a significant increase in the expression of fibronectin (c) (P < 0.05), and a significant increase in the expression of α-smooth muscle actin (d) (P < 0.05), mean ± SEM unpaired t- test. (NB: Original blots ‘BMC Additional file 7)

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