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Fig. 5 | BMC Nephrology

Fig. 5

From: A novel model of reno-cardiac syndrome in the C57BL/ 6 mouse strain

Fig. 5

Evidence for renal hypertrophy through staining with sirius red and immunostaining for α-SMA, collagen 1, and collagen 3. Control group (n = 6) received standard chow for 20 weeks. Adenine treated group (n = 10) received standard chow with the addition of 0.15% adenine for 20 weeks. Immunostaining of kidneys showed a significant increase in α-SMA staining of adenine group (b) compared to control group (a) (P < 0.0001). A significant increase in collagen 1 staining of adenine group (d) compared to control group (c) (P < 0.0001). A significant increase in collagen 3 staining of adenine group (f) compared to control group (e) (P < 0.0001), and a significant increase in sirius red staining of adenine group (h) compared to control group (g) (P < 0.0001), mean ± SEM unpaired t- test. Representational images (3 mice per group)

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