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Fig. 7 | BMC Nephrology

Fig. 7

From: A novel model of reno-cardiac syndrome in the C57BL/ 6 mouse strain

Fig. 7

Evidence for cardiac and renal inflammation through immunostaining for F4/80 and CD45. Control group (n = 6) received standard chow for 20 weeks. Adenine treated group (n = 10) received standard chow with the addition of 0.15% adenine for 20 weeks. Immunostaining of hearts and kidneys showed a significant decrease in F480 staining of adenine group (b, hearts and f, kidneys) compared to control group (a, hearts and e, kidneys) (P < 0.0001). Immunostaining of hearts and kidneys for CD45 showed a significant increase in staining of adenine group (d, hearts and h, kidneys) compared to control group (c, hearts and g, kidneys) (P < 0.0001), mean ± SEM unpaired t- test. Representational images (3 mice per group)

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