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Table 1 Biochemistry showing renal dysfunction

From: A novel model of reno-cardiac syndrome in the C57BL/ 6 mouse strain

Parameter Control Adenine
No. 6 10
Serum urea, mmol/L 8.867 ± 0.4240 81.57 ± 1.809 ***
Serum creatinine, μmol/L 16.83 ± 3.554 114.5 ± 5.909 ***
Serum calcium, mmol/L 1.983 ± 0.01667 2.760 ± 0.08055 ***
Serum sodium, mmol/L 154.3 ± 1.333 156.5 ± 0.7491
Serum potassium, mmol/L 5.430 ± 0.1762 6.019 ± 0.07275 *
Serum i. phosphate, mmol/L 2.550 ± 0.08466 2.750 ± 0.1455
Urine flow ml/min 0.0003518 ± 0.00008339 0.002882 ± 0.0002918 ***
Urine sodium, mmol/L 218.3 ± 27.03 59.06 ± 3.652 ***
Urine potassium, mmol/L 293.9 ± 59.58 100.3 ± 8.498 ***
FE sodium, % 8208 ± 1883 99,690 ± 9764 ***
FE potassium, % 424.1 ± 127.3 6223 ± 384.0 ***
GFR, ml/min 0.1642 ± 0.04598 0.02869 ± 0.003854 *
  1. Control group (n = 6) received standard chow for 20 weeks. Adenine treated group (n = 10) received standard chow with the addition of 0.15% adenine for 20 weeks. Compared with animals receiving normal chow, a 20-week diet of 0.15% adenine caused significant increases in plasma urea (P < 0.0001), creatinine (P < 0.0001), calcium (P < 0.0001), and potassium (P < 0.05) concentrations. Adenine treated animals were significantly polyuric (P < 0.0001). The glomerular filtration rate (GFR) assessed by creatinine clearance was significantly reduced (P < 0.05), whereas the fractional excretion of sodium and potassium were significantly increased (P < 0.0001), mean ± SEM unpaired t- test
  2. ***P < 0.0001
  3. *P < 0.05