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Table 1 Biochemistry showing renal dysfunction

From: A novel model of reno-cardiac syndrome in the C57BL/ 6 mouse strain

Parameter

Control

Adenine

No.

6

10

Serum urea, mmol/L

8.867 ± 0.4240

81.57 ± 1.809 ***

Serum creatinine, μmol/L

16.83 ± 3.554

114.5 ± 5.909 ***

Serum calcium, mmol/L

1.983 ± 0.01667

2.760 ± 0.08055 ***

Serum sodium, mmol/L

154.3 ± 1.333

156.5 ± 0.7491

Serum potassium, mmol/L

5.430 ± 0.1762

6.019 ± 0.07275 *

Serum i. phosphate, mmol/L

2.550 ± 0.08466

2.750 ± 0.1455

Urine flow ml/min

0.0003518 ± 0.00008339

0.002882 ± 0.0002918 ***

Urine sodium, mmol/L

218.3 ± 27.03

59.06 ± 3.652 ***

Urine potassium, mmol/L

293.9 ± 59.58

100.3 ± 8.498 ***

FE sodium, %

8208 ± 1883

99,690 ± 9764 ***

FE potassium, %

424.1 ± 127.3

6223 ± 384.0 ***

GFR, ml/min

0.1642 ± 0.04598

0.02869 ± 0.003854 *

  1. Control group (n = 6) received standard chow for 20 weeks. Adenine treated group (n = 10) received standard chow with the addition of 0.15% adenine for 20 weeks. Compared with animals receiving normal chow, a 20-week diet of 0.15% adenine caused significant increases in plasma urea (P < 0.0001), creatinine (P < 0.0001), calcium (P < 0.0001), and potassium (P < 0.05) concentrations. Adenine treated animals were significantly polyuric (P < 0.0001). The glomerular filtration rate (GFR) assessed by creatinine clearance was significantly reduced (P < 0.05), whereas the fractional excretion of sodium and potassium were significantly increased (P < 0.0001), mean ± SEM unpaired t- test
  2. ***P < 0.0001
  3. *P < 0.05