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Table 2 Cardiac dysfunction

From: A novel model of reno-cardiac syndrome in the C57BL/ 6 mouse strain

Parameter Control Adenine
No. 6 10
Ejection fraction, % 72.84 ± 1.425 65.14 ± 0.8203 ***
Fractional shortening, % 41.17 ± 1.092 35.41 ± 0.6011 ***
Fractional area change, % 49.82 ± 0.6524 42.80 ± 1.149 ***
LVID, mm 3.832 ± 0.1192 4.257 ± 0.04804 *
IVS, mm 0.9647 ± 0.08316 1.039 ± 0.04658
Heart/bodyweight ratio 0.004341 ± 0.0001352 0.006031 ± 0.0001553 ***
  1. Control group (n = 6) received standard chow for 20 weeks. Adenine treated group (n = 10) received standard chow with the addition of 0.15% adenine for 20 weeks. Echocardiography showed slight, but significant, reductions in percentage of ejection fraction, fractional shortening, and fractional area change (P < 0.0001). There was an increase in left ventricular dimensions (left ventricular internal diastolic dimension (LVID) and left ventricular end Diastolic volume; P < 0.05), and a significantly greater heart weight-to body weight ratio (P < 0.0001), mean ± SEM unpaired t- test
  2. ***P < 0.0001
  3. *P < 0.05