Serum heat shock protein 27 levels predict cardiac mortality in hemodialysis patients

BMC Nephrology

Table 4 Uni- and multivariate predictors of cardiovascular mortality

Parameter	Univariate HR (95% CI)	p	Multivariate HR (95% CI)	p
Age	2.18 (1.51–2.71)	< 0.001	1.68 (1.25–2.21)	< 0.001
Diabetes mellitus	1.13 (0.49–2.27)	0.274
History of MI	1.51 (0.92–2.24)	0.008	1.39 (0.71–2.49)	0.136
LVMI	2.41 (1.65–3.23)	0.105	1.86 (0.93–3.12)	0.345
EF	1.28 (0.61–2.45)	0.219
TOC	1.75 (1.26–2.44)	0.011	1.53 (1.11–2.79)	0.214
TAC	1.86 (1.01–3.44)	0.257
oxLDL	1.49 (0.93–2.65)	0.163
Phosphate	0.89 (0.33–1.97)	0.311
Hemoglobin	1.62 (0.98–2.67)	0.247
Troponin T	1.84 (1.35–2.59)	0.007	1.72 (1.24–2.34)	0.008
CRP	1.35 (0.75–1.82)	0.024	1.15 (0.43–1.98)	0.211
IMT	1.46 (0.85–1.83)	0.019	1.37 (0.52–2.11)	0.136
Number of plaques	1.23 (0.63–2.29)	0.279
HSP-27	3.97 (3.49–4.58)	< 0.001	3.23 (2.67–3.71)	< 0.001

In multivariate analysis included were all variables with a p value < 0.15 in the univariate analysis. HR hazard ratio, CI confidence interval, MI myocardial infarction, LVMI left ventricular mass index, EF ejection fractionm, TOC total oxidant capacity, TAC total antioxidant capacity, oxLDL oxidized LDL, CRP C-reactive protein, IMT intima-media thickness, HSP-27 heat shock protein 27. In the multivariate analyses, parameters with a p ≤ 0.15 were entered

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