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Table 3 Laboratory parameters

From: A prospective observational study of iron isomaltoside in haemodialysis patients with chronic kidney disease treated for iron deficiency (DINO)

 

Retrospective IS phase

Prospective IIM phases

 

0–3 months

0–3 months

3–6 months

6–9 months

9–12 months

Hb (g/dL)

n = 195

n = 195

n = 183

n = 178

n = 166

Hb level

     

Mean (SD)

11.1 (1.0)

11.4 (0.9)

11.2 (1.0)

11.1 (1.1)

11.2 (0.9)

p-valuea

 

0.0151

0.4154

0.8695

0.7934

Hb change vs. IS phase

     

Mean (SD)

 

0.3 (1.2)

0.1 (1.3)

0.0 (1.4)

0.0 (1.2)

Ferritin (μg/L)

     

Ferritin level

n = 187

n = 190

n = 182

n = 175

n = 159

Mean (SD)

395.5 (231.4)

395.1 (224.3)

420.4 (224.3)

408.4 (231.1)

420.8 (253.1)

Median (IQR)b

366.7 (227.5–519.0)

364.3 (222.7–523.0)

391.5 (261.3–553.3)

356.0 (236.7–549.0)

390.0 (223.0–590.0)

p-valuea

 

0.9135

0.1799

0.5429

0.4434

Ferritin change vs. IS phase

 

n = 184

n = 175

n = 168

n = 152

Mean (SD)

 

4.2 (180.4)

28.4 (209.0)

9.6 (206.7)

16.8 (217.5)

Median (IQR)b

 

−20.3 (−93.7–93.4)

9.8 (−86.2–159.0)

−5.3 (−102–124.7)

4.7 (− 88.9–129.5)

TSAT (%)

     

TSAT level

n = 187

n = 191

n = 182

n = 175

n = 159

Mean (SD)

25.0 (8.8)

26.8 (9.8)

26.4 (10.2)

26.2 (9.7)

26.7 (10.0)

p-valuea

 

0.0592

0.4014

0.2828

0.1517

TSAT change vs. IS phase

 

n = 185

n = 175

n = 168

n = 152

Mean (SD)

 

1.8 (9.4)

1.0 (8.5)

0.9 (9.4)

1.3 (9.8)

CRP (mg/L)

     

CRP level

n = 139

n = 129

n = 109

n = 122

n = 117

Mean (SD)

12.4 (14.8)

21.6 (35.1)

19.5 (25.5)

19.4 (27.9)

18.8 (23.6)

Median (IQR)b

7.0 (3.3–15.3)

8.7 (4.9–22.0)

10.0 (6.0–21.5)

10.0 (4.7–19.5)

10.0 (5.0–23.0)

p-valuea

 

0.0351

0.0030

0.0143

0.0131

CRP change vs. IS phase

 

n = 124

n = 104

n = 112

n = 108

Mean (SD)

 

8.9 (33.9)

6.8 (21.8)

6.3 (19.9)

7.2 (21.6)

Median (IQR)b

 

0.8 (−1.5–7.0)

2.6 (−0.8–7.8)

1.6 (−1.1–10.8)

1.4 (−1.5–11.2)

  1. aP-value obtained from Wilcoxon rank-sum test by comparison to the retrospective IS phase
  2. bData not normally distributed are presented as median values
  3. CRP C-reactive protein, Hb haemoglobin, IIM iron isomaltoside, IQR interquartile range, IS iron sucrose, IU international unit, IV intravenous, n number of patients, SD standard deviation, TSAT transferrin saturation