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Table 1 Past reports of HUS related to pertussis infection

From: Treatment of hemolytic uremic syndrome related to Bordetella pertussis infection —is plasma exchange or eculizumab use necessary?

 

1

2

3

4

5

6

The present case

The Age of Onset

20 days

6 weeks

4 weeks

24 days

2 months

1 month

1 month

Sex

M

F

M

F

M

F

F

Duration of Pertussis infection leading to HUS

6 weeks

16 days

21 days

17 days

12 days

18 days

19 days

Intubation

+

+

+

+

+

LDH

1200

1950

5259

2642

unknown

3268

4428

Plasma therapy

PI

PI

PE

PE

PI, PE

Dialysis

PD

HD

PD

HD

ECZ

+

Antibiotics

EM

CTX, EM

AMPC, CTX, CAM

AZM

AZM

PIPC, CTX, CAM

PIPC, CAM

Steroid

+

+

+

CH50, C3, C4

Normal

Normal

Normal

Normal

Normal

Decreased

Gene mutation

CFH

unknown

THBD

Prognosis

Death

Alive

Alive

Alive

Alive

Alive

Alive

Follow-up (year)

2

0.6

unknown

1

2.5

3

Author

Berner R. et al. [3]

Pela I. et al. [11]

Chaturvedi S. et al. [4]

Obando I. et al. [12]

Cohen-Ganelin E. et al. [13]

Ito N. et al. [14]

 

Reported year

2002

2006

2010

2012

2012

2014

2018

  1. Abbreviations: LDH Lactate dehydrogenase, ECZ Eculizumab, PI Plasma Infusion, PE Plasma Exchange, PD Peritoneal
  2. Dialysis, HD Hemodialysis, EM Erythromycin, CTX Cefotaxime, AMPC Amoxicillin, CAM Clarithromycin,
  3. AZM Azithromycin, PIPC Piperacillin