Association of plasma somatostatin with disease severity and progression in patients with autosomal dominant polycystic kidney disease

Table 3 Association of plasma SST concentration with parameters of disease severity in patients receiving standard care

	Crude		Model 1		Model 2		Model 3		Model 4
	St. β	p	St. β	p	St. β	p	St. β	p	St. β	p
Baseline mGFR (ml/min/1.73m²)
Log SST	−0.25	0.004	−0.13	0.06	−0.10	0.14	−0.10	0.21	−0.12	0.14
Female sex			0.05	0.47	−0.02	0.75	−0.02	0.79	0.03	0.76
Age (yrs)			−0.59	< 0.001	−0.57	< 0.001	−0.63	< 0.001	−0.62	< 0.001
htTKV (ml/m)					−0.33	< 0.001	−0.34	< 0.001	−0.34	< 0.001
PKD2 (ref)^a
PKD1 truncating							−0.30	0.02	−0.29	0.02
PKD1 non-truncating							−0.27	0.03	−0.26	0.03
Protein intake (g/24 h)									0.14	0.10
Baseline log htTKV
Log SST	0.21	0.02	0.13	0.15	0.06	0.50	0.05	0.62	0.04	0.71
Female sex			−0.26	0.004	−0.23	0.004	−0.24	0.02	−0.21	< 0.05
Age (yrs)			0.17	0.05	−0.15	0.13	−0.16	0.22	−0.16	0.22
mGFR (ml/min/1.73m²)					−0.55	< 0.001	−0.56	< 0.001	−0.57	< 0.001
PKD2 (ref)^a
PKD1 truncating							−0.05	0.73	−0.05	0.74
PKD1 non-truncating							−0.15	0.31	−0.15	0.31
Protein intake (g/24 h)									0.07	0.50

Standardized beta’s and p-values were calculated using linear regression analysis. Dependent variable is mGFR or log transformed htTKV, independent variable is the log transformed SST concentration
Abbreviations are: SST somatostatin, mGFR measured GFR, htTKV height adjusted total kidney volume, PKD polycystic kidney disease St. β, standardized beta, p p-value
Model 1: adjusted for age and sex
Model 2: adjusted for age, sex and htTKV or mGFR
Model 3: adjusted for age, sex and htTKV or mGFR and PKD mutation
Model 4: adjusted for age, sex and htTKV or mGFR, PKD mutation and protein intake
^aPKD mutation was used as dummy variable with PKD2 as reference group

ISSN: 1471-2369