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Table 2 Baseline characteristics of apparently healthy young men in northwest Nicaragua stratified by trajectories of a future decline in kidney function using gold standard measurements (CKDEPI Creat/Cyst eGFR) (n = 263)

From: Identification of young adults at risk of an accelerated loss of kidney function in an area affected by Mesoamerican nephropathy

Trajectories of the decline in kidney function N Age at baseline (Mean; SD) Serum creatinine level at baseline‡ (Median; IQR) eGFRScr at baseline‡ (Median; IQR) eGFRScr-Scys at baseline† (Median; IQR) Urinary NGAL level at baseline (Median; IQR) UACR ≥30 mg/dL at baseline (n; %) Outdoor work at baseline (n; %)
Stable kidney function (−0.6 mL/min/1.73 m2/year) 213 23.6 ± 3.89 0.76 (0.57–0.76) 131 (124–140) 118 (108–125) 5.04 (4.7–5.4) 10 (4.7) 151 (70.9)
Rapid decline in kidney function (− 18.2 mL/min/1.73 m2/year) 25 23.3 ± 3.65 0.66 (0.47–0.76) 132 (123–152) 117 (103–124) 5.20 (5.0–5.5) 0 (0) 24 (96.0)
Renal dysfunction (− 3.8 mL/min/1.73 m2/year) 25 25.4 ± 2.97 1.23 (1.14–1.52) 80 (62–91) 56 (49–68) 5.7 (5.5–5.7) 4 (16.0) 19 (76.0)
Total 263 23.7 ± 3.82 0.76 (0.66–0.85) 129 (121–139) 116 (102–125) 5.20 (4.9–5.7) 14 (5.3) 194 (73.8)
  1. ‡Routine local test measurement. †Gold-standard outcome measured in Oxford 2 years later. Urinary biomarkers of kidney injury