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Table 3 HRs and 95% CI of albuminuria, eGFR decrease and DKD incidence according to baseline 25(OH)D level

From: Serum 25-Hydroxyvitamin D were associated with higher risk of both albuminuria and impaired GFR incidence: a cohort study based on CLHLS study

 

Variable type

HR* (95%CI)

P

Albuminuria

Continuous variable

0.952 (0.941–0.963)

< 0.001

Classifications

 

< 0.001

  < 50 nmol/L

5.737 (2.807–11.725)

 

 50–75 nmol/L

1.695 (0.684–4.200)

 

  ≥ 75 nmol/L

1.00 (Ref)

 

Quintiles

 

< 0.001

  ≤ 30 nmol/L

7.864 (4.012–14.717)

 

 30–40 nmol/L

5.631 (2.824–11.228)

 

 40–50 nmol/L

3.328 (1.571–7.050)

 

 50-63 nmol/L

1.302 (0.485–3.495)

 

 >63 nmol/L

1.00 (Ref)

 

Impaired eGFR

Continuous variable

0.975 (0.966–0.983)

< 0.001

Classifications

 

< 0.001

  < 50 nmol/L

4.329 (2.015–9.300)

 

 50–75 nmol/L

2.068 (0.920–4.649)

 

  ≥ 75 nmol/L

1.00 (Ref)

 

Quintiles

 

< 0.001

  ≤ 30 nmol/L

4.645 (2.808–7.684)

 

 30–40 nmol/L

4.120 (2.460–6.900)

 

 40–50 nmol/L

2.750 (1.598–4.732)

 

 50-63 nmol/L

2.010 (1.156–3.495)

 

 >63 nmol/L

1.00 (Ref)

 

CKD

Continuous variable

0.966 (0.959–0.973)

0.003

Classifications

 

< 0.001

  < 50 nmol/L

4.667 (2.285–9.532)

 

 50–75 nmol/L

1.811 (0.909–3.608)

 

  ≥ 75 nmol/L

1.00 (Ref)

 

Quintiles

 

< 0.001

≤30 nmol/L

5.677 (3.771–8.546)

 

 30–40 nmol/L

4.410 (2.892–6.724)

 

 40–50 nmol/L

2.832 (1.810–4.431)

 

 50-63 nmol/L

1.821 (1.138–2.914)

 

 >63 nmol/L

1.00 (Ref)

 
  1. Adjusted for age, gender, marital status, illiteracy, current smoking, current alcohol drinking, current exercise, baseline BMI, ALB, BUN, CRE, SUA, baseline prevalence of hypertension, diabetes, heart disease and stroke