Table 2 Clinical and histological presentation at the time of first and second renal biopsy

Clinical presentation

CGN

RPGN

U-P 3.2 g/g·Cr

U-P 12.3 g/g·Cr

U-RBC 50–99/HPF

U-RBC > 100/HPF

sCr 0.74 mg/dL

sCr 5.5 mg/dL

Anti-GBM antibody

Not tested

116 IU/ml

Light microscopy

Mesangial proliferative GN

Crescentic GN

Global sclerosis (1/19)

Global sclerosis (6/31)

Fibrocellular crescent (1/19)

Cellular~fibrocellular crecent (18/31)

Immunofluorescence

IgA: mes ++

IgA: mes +

C3: mes ++

C3: mes +

IgG: mes +,

 peripheral linear +

 peripheral linear ±

IgG: peripheral linear ++

 (focal segmental)

 (diffuse global)