The effects of add-on corticosteroids on renal outcomes in patients with biopsy proven HIV associated nephropathy: a single centre study from South Africa

Table 1 Baseline demographic, clinical and biochemical parameters

	ALL N = 38	[ART + C] N = 21	[ART Alone] N = 17	P Value*
Demographics
Gender (female), n[%]	25 [65.8%]	14 [66.7%]	11 [64.7%]	0.899^a
Age (years) median IQR	33 [2;39]	36 [27;42]	28 [25;34]	0.050^b
Clinical parameters
Systolic BP (mmHg) median [IQR]	118 [110;125]	118 [110;125]	118 [110;121]	0.668^b
Diastolic BP (mmHg median [IQR]	77 [71;83]	76 [65;80]	77 [71;84]	0.561^b
Diabetes; n [%}	1 [2.6%]	1 [4.8%]	0	1.000^a
Hypertension, n [%}	7 [18.4%]	5 [23.8%]	2 [11.8%]	0.306^a
Tuberculosis at baseline, n [%}	10 [26.3]	7 [33.3%]	3 [17.6%]	0.242^a
Commenced on ACE/ARB; n [%}	27 [71.1%]	14 [66.7%]	12 [70.6%]	0.519^a
ART regimen at baseline, n [%}				0.332^a
- D4T/3TC/EFV or NEV	20 [52.6%]	11 [52.4%]	9 [52.9%]
- ABC/3TC/EFV or NEV	9 [23.7%]	7 [33.3%]	2 [11.8%]
- ZVD/3TC/EFV or NEV	6 [15.8%]	2 [9.5%]	4 [23.5%]
- Other/unknown	3 [7.9%]	1 [4.8%]	2 [11.8%]
Biochemical parameters
eGFR (ml/min/1.73m²) median[IQR]	43.5 [26;70]	35 [18;46]	47 [39;97]	0.015^b
eGFR (ml/min/1.73m²) mean [SD]	50 [32.8]	37.8 [26.0]	65.1 [34.8]
CD4 (cells/mm³) median[IQR]	158 [63;309]	158 [36;272]	173 [104;352]	0.437^b
HIV VL (Log 10) (cps/ml) median[IQR]	4.77 [3.87;5.29]	4.77 [4.5;5.29]	4.69 [2.75;5.3]	0.5623^b
Albumin (g/L) median[IQR]	30 [25;33]	29 [24;32]	30.5 [27;36]	0.262^b
uPCR (g/mmol) median[IQR]	0.36 [0.14;0.54]	0.43 [0.17;0.52]	0.23 [0.13;0.60]	0.617^b
Haemoglobin (g/dL) median[IQR]	8.1 [7.3;10.2]	8.0 [7.4;9.9]	8.1 [7.3;10.2]	0.872^b
Cholesterol(mmol/l) median[IQR]	4.5 [3.6;5.6]	4.4 [3.3;5.1]	4.8 [3.9;6.0]	0.347^b

ART + C Antiretrovirals + corticosteroids, ART Alone Antiretrovirals alone, IQR interquartile range, BP Blood pressure, ACEi angiotensin converting enzyme inhibitor, ARB angiotensin receptor blocker, D4T Stavudine, 3TC Lamivudine, NEV Nevirapine, ABC Abacavir, EFV Efavirenz, ZVD Zidovudine, uPCR urine protein-to-creatinine ratio, HIV VL HIV viral load, eGFR estimated glomerular filtration rate, SD standard deviation. a = Fishers Exact test, b = Wilcoxon Rank-Sum test, * p-value comparison of [ART+C] vs [ART Alone]

ISSN: 1471-2369