Skip to main content

Table 1 Baseline demographic, clinical and biochemical parameters

From: The effects of add-on corticosteroids on renal outcomes in patients with biopsy proven HIV associated nephropathy: a single centre study from South Africa

  ALL
N = 38
[ART + C]
N = 21
[ART Alone]
N = 17
P Value*
Demographics
 Gender (female), n[%] 25 [65.8%] 14 [66.7%] 11 [64.7%] 0.899a
 Age (years) median IQR 33 [2;39] 36 [27;42] 28 [25;34] 0.050b
Clinical parameters
 Systolic BP (mmHg) median [IQR] 118 [110;125] 118 [110;125] 118 [110;121] 0.668b
 Diastolic BP (mmHg median [IQR] 77 [71;83] 76 [65;80] 77 [71;84] 0.561b
 Diabetes; n [%} 1 [2.6%] 1 [4.8%] 0 1.000a
 Hypertension, n [%} 7 [18.4%] 5 [23.8%] 2 [11.8%] 0.306a
 Tuberculosis at baseline, n [%} 10 [26.3] 7 [33.3%] 3 [17.6%] 0.242a
 Commenced on ACE/ARB; n [%} 27 [71.1%] 14 [66.7%] 12 [70.6%] 0.519a
 ART regimen at baseline, n [%}   0.332a
 - D4T/3TC/EFV or NEV 20 [52.6%] 11 [52.4%] 9 [52.9%]  
 - ABC/3TC/EFV or NEV 9 [23.7%] 7 [33.3%] 2 [11.8%]
 - ZVD/3TC/EFV or NEV 6 [15.8%] 2 [9.5%] 4 [23.5%]
 - Other/unknown 3 [7.9%] 1 [4.8%] 2 [11.8%]
Biochemical parameters
 eGFR (ml/min/1.73m2) median[IQR] 43.5 [26;70] 35 [18;46] 47 [39;97] 0.015b
 eGFR (ml/min/1.73m2) mean [SD] 50 [32.8] 37.8 [26.0] 65.1 [34.8]  
 CD4 (cells/mm3) median[IQR] 158 [63;309] 158 [36;272] 173 [104;352] 0.437b
 HIV VL (Log 10) (cps/ml) median[IQR] 4.77 [3.87;5.29] 4.77 [4.5;5.29] 4.69 [2.75;5.3] 0.5623b
 Albumin (g/L) median[IQR] 30 [25;33] 29 [24;32] 30.5 [27;36] 0.262b
 uPCR (g/mmol) median[IQR] 0.36 [0.14;0.54] 0.43 [0.17;0.52] 0.23 [0.13;0.60] 0.617b
 Haemoglobin (g/dL) median[IQR] 8.1 [7.3;10.2] 8.0 [7.4;9.9] 8.1 [7.3;10.2] 0.872b
 Cholesterol(mmol/l) median[IQR] 4.5 [3.6;5.6] 4.4 [3.3;5.1] 4.8 [3.9;6.0] 0.347b
  1. ART + C Antiretrovirals + corticosteroids, ART Alone Antiretrovirals alone, IQR interquartile range, BP Blood pressure, ACEi angiotensin converting enzyme inhibitor, ARB angiotensin receptor blocker, D4T Stavudine, 3TC Lamivudine, NEV Nevirapine, ABC Abacavir, EFV Efavirenz, ZVD Zidovudine, uPCR urine protein-to-creatinine ratio, HIV VL HIV viral load, eGFR estimated glomerular filtration rate, SD standard deviation. a = Fishers Exact test, b = Wilcoxon Rank-Sum test, * p-value comparison of [ART+C] vs [ART Alone]