Cohort/ subgroup | Measurement time A (1 [1–2] day p.o.) | Measurement time B (4 [2–6] days p.o.) | Measurement time C (47 [30–105] days p.o.) | Measurement time D (13 [12–15] months p.o.) | Measurement time E (50 [35–81] months p.o.) | p-value |
---|---|---|---|---|---|---|
NSS-C | −16.8 [−27.0 - −7.9] | −9.9 [−19.1–0.0] | −9.1 [−23.2–0.0] | −7.8 [−20.4–0.25] | −10.4 [−20.2 - −1.2] | < 0.001 |
n = 444 (100.0%) | −22.6% [−36.2% - −9.7%] | −13.0% [−24.9%–0.0%] | −12.5% [−27.2%–0.0%] | −11.0% [−26.3%–0.3%] | −14.1% [−27.7% - −1.3%] | < 0.001* |
n = 436 (98.2%) | n = 436 (98.2%) | n = 184 (41.4%) | n = 203 (45.7%) | n = 234 (52.7%) | ||
NSS-RI | − 17.7 [− 27.8 - −9.1] | −10.2 [− 19.8 - −1.2] | −9.7 [− 23.8–0.1] | −8.6 [−21.0–0.6] | −10.0 [− 19.6–0.67] | < 0.001 |
n = 343 (100.0%) | − 24.0% [− 38.0% - −10.9%] | − 13.7% [− 25.5%- −1.5%] | − 19.3% [− 37.2%–5.5%] | − 15.8% [− 35.3%–6.1%] | − 11.5% [− 33.4%–9.8%] | < 0.001* |
n = 337 (98.3%) | n = 337 (98.3%) | n = 148 (43.1%) | n = 161 (46.9%) | n = 183 (53.4%) | ||
NSS-NRI | −12.6 [− 23.8–1.3] | −4.7 [− 17.5–4.7] | −1.9 [− 21.9–5.7] | −6.6 [− 14.0–2.6] | − 12.1 [− 25.7 - −1.2] | 0.15 |
n = 57 (100.0%) | − 17.5% [−31.9%–2.1%] | − 7.4% [− 21.3%–9.5%] | −2.9% [− 25.0%–6.6%] | − 9.4% [− 22.7%–5.3%] | − 14.8% [− 44.5% - −1.4%] | 0.15* |
n = 57 (100.0%) | n = 57 (100.0%) | n = 25 (43.9%) | n = 28 (49.1%) | n = 34 (59.6%) | ||
p-value | 0.01 | 0.03 | 0.1 | 0.43 | 0.28 | Â |
0.007* | 0.01* | 0.07* | 0.35* | 0.13* | ||
LNSS-RI | −13.3 [− 25.3 - −7.1] | −8.0 [− 17.5–0.0] | −7.7 [− 23.4 - −0.4] | −7.4 [− 20.1 - −1.0] | −9.0 [− 18.4 - −0.1] | < 0.001 |
n = 185 (100.0%) | − 17.0% [−30.5% - −9.0%] | − 10.1% [− 21.6%–0.0%] | − 10.5% [− 27.7% - −0.5%] | − 10.8% [− 23.0% - −1.3%] | − 9.8% [− 23.4%–1.8%] | < 0.001* |
n = 183 (98.9%) | n = 183 (98.9%) | n = 76 (41.0%) | n = 90 (48.6%) | n = 102 (55.1%) | ||
ONSS-RI | −22.8 [− 31.0 - −13.2] | − 13.7 [− 22.1 - −4.1] | −11.5 [− 24.2–0.0] | −10.7 [− 23.4 - −0.3] | − 12.6 [− 23.7 - −2.0] | < 0.001 |
n = 158 (100.0%) | − 31.1% [− 44.1% - −18.5%] | − 19.8% [−29.9% - −6.1%] | − 16.2% [−28.0% - −16.2%] | − 15.9% [−32.5% - −0.3%] | − 14.7% [− 30.3% - −2.9%] | < 0.001* |
n = 154 (97.5%) | n = 154 (97.5%) | n = 72 (45.6%) | n = 71 (44.9%) | n = 81 (51.6%) | ||
p-value | < 0.001 | < 0.001 | 0.58 | 0.49 | 0.06 |  |
< 0.001* | < 0.001* | 0.45* | 0.37* | 0.06* | ||
NSS-AKI | −27.7 [−36.8 - −23.3] | − 17.3 [− 26.6 - −11.7] | −16.4 [− 25.9 - − 4.5] | −13.8 [− 24.0 - −5.2] | −14.7 [− 24.5 - −5.4] | < 0.001 |
n = 126 (100.0%) | −37.5% [− 46.8% - −30.9%] | − 25.2% [− 32.4% - −15.2%] | − 22.4% [−34.0% - −7.7%] | − 22.7% [− 33.5% - −10.2%] | − 21.6% [− 31.0% - −8.8%] | < 0.001* |
n = 126 (100.0%) | n = 126 (100.0%) | n = 60 (47.6%) | n = 65 (51.5%) | n = 68 (53.9%) | ||
NSS-NAKI | −9.8 [− 16.8- −1.6] | −3.4 [− 10.4–4.9] | −5.0 [− 14.0–2.0] | −5.0 [− 13.5–2.0] | −7.2 [− 17.3–3.0] | < 0.001 |
n = 201 (100.0%) | − 12.1% [− 20.1% - −1.8%] | − 4.2% [− 13.3% - −6.8%] | − 6.8% [− 17.1%–3.4%] | − 6.6% [− 18.3%–2.6%] | − 9.4% [− 21.2%–4.4%] | 0.004* |
n = 201 (100.0%) | n = 201 (100.0%) | n = 80 (39.8%) | n = 92 (45.8%) | n = 109 (54.2%) | ||
p-value | < 0.001 | < 0.001 | < 0.001 | < 0.001 | < 0.001 |  |
< 0.001* | < 0.001* | < 0.001* | < 0.001* | < 0.001* | ||
NSS-G1 | − 18.0 [− 32.7 - −7.5] | − 10.9 [− 24.4 - −0.6] | −20.4 [− 30.3 - − 5.4] | −10.3 [− 31.0 - − 0.5] | −13.0 [− 31.9 - − 4.9] | 0.04 |
n = 134 (100.0%) | − 19.5% [− 30.6% - −7.4%] | − 10.6% [− 22.9% - −0.7%] | − 21.0% [− 28.7% - −5.7%] | − 10.6% [− 29.8% - −0.1%] | − 13.2% [− 29.8% - −5.1%] | 0.04* |
n = 133 (99.0%) | n = 133 (99.0%) | n = 42 (31.3%) | n = 46 (34.3%) | n = 62 (46.3%) | ||
NSS-G2 | −17.8 [− 27.6 - −8.6] | −10.4 [− 18.0 - −1.1] | −9.7 [− 22.7 - − 0.1] | −10.0 [− 21.5 - − 0.3] | −10.2 [− 19.6 - − 0.7] | < 0.001 |
n = 223 (100.0%) | − 24.5% [− 36.5% - −11.0%] | − 13.4% [− 24.5% - −1.2%] | − 12.3% [− 27.2% - −0.1%] | − 12.5% [− 27.2% - −0.4%] | − 14.1% [− 24.0% - −0.9%] | < 0.001* |
n = 221 (99.0%) | n = 221 (99.0%) | n = 104 (46.6%) | n = 120 (53.8%) | n = 131 (58.7%) | ||
NSS ≥ G3 | −13.6 [− 22.8 - −3.4] | −5.1 [− 13.9–1.3] | −3.4 [− 9.1–2.4] | − 4.8 [− 10.6–2.1] | −7.2 [− 15.3–0.9] | < 0.001 |
n = 82 (100.0%) | − 29.3% [− 46.4% - −9.3%] | − 13.5% [− 29.3%–4.1%] | − 7.9% [− 17.1% - 7.4%] | − 9.0% [− 22.0%–4.6%] | − 14.7% [− 29.9%–1.8%] | < 0.001* |
n = 82 (100.0%) | n = 82 (100.0%) | n = 38 (46.3%) | n = 37 (45.1%) | n = 42 (51.2%) | ||
p-value | 0.02 | 0.007 | < 0.001 | 0.03 | 0.02 |  |
0.004* | 0.78* | 0.03* | 0.43* | 0.6* |