Table 1 Patient characteristics at renal replacement therapy (RRT) inception, by era. All results are presented as median (interquartile range) or n(%)

N

9351

7207

2144

Age (years)*

58 (47, 71)

59 (47, 72)

56 (44, 67)

Gender*

Male

5613 (60%)

4247 (59%)

1366 (64%)

Female

3738 (40%)

2960 (41%)

778 (36%)

Cause of ESKF

Primary

3892 (42%)

2969 (41%)

923 (43%)

Secondary

3472 (37%)

2714 (38%)

758 (35%)

Other

1987 (21%)

1524 (21%)

463 (22%)

BMI (kg/m²)*

22.2 (20.0, 24.8)

22.2 (20, 24.7)

22.5 (20.3, 25.0)

Weight (kg)*

61.6 (53.8, 69.7)

61.1 (53.5, 69.0)

63.2 (54.9, 71.8)

Height (m)*

1.67 (1.60, 1.72)

1.66 (1.60, 1.72)

1.68 (1.60, 1.73)

Hemoglobin (g/L)

All patients

97.1 (81.9, 111.0)

97.1 (81.5, 111.0)

97.3 (82.0, 111.1)

> = 3 x week RRT

97 (81, 111)

97 (81, 111)

97 (81, 111)

> = 3 x week RRT & Kt/V > =1.2

98.2 (82.4, 111.9)

98.1 (82.2, 111.8)

96.5 (83, 112.1)

eGFR (mL/min/1.73m²)

All patients

6.0 (4.5, 8.2)

6.0 (4.5, 8.3)

6.0 (4.5, 8.1)

> = 3 x week RRT

6.1 (4.6, 8.5)

6.2 (4.6, 8.6)

6.0 (4.5, 8.2)

> = 3 x week RRT & Kt/V > =1.2

6.3 (4.7, 8.6)

6.4 (4.7, 8.7)

6.2 (4.6, 8.3)

Creatinine Index (mg/kg/day)

All patients*

21.2 (19.0, 23.7)

21.2 (18.9, 23.6)

21.5 (19.3, 23.9)

> = 3 x week RRT*

21.2 (18.9, 23.5)

21.0 (18.8, 23.4)

21.4 (19.2, 23.8)

> = 3 x week RRT & Kt/V > =1.2*

21.1 (18.9, 23.5)

20.9 (18.8, 23.3)

21.5 (19.3, 23.7)

Albumin (g/L)

All patients*

36 (31.8, 40.2)

36 (31.5, 40)

36.8 (32, 40.9)

> = 3 x week RRT*

36 (31, 40)

36 (31, 40)

36.5 (32, 40.7)

> = 3 x week RRT & Kt/V > =1.2*

36.8 (32, 40.8)

36.4 (32.0, 40.3)

37.1 (32.9, 41.0)

Total Cholesterol (mM)

4.0 (3.3, 4.8)

4.0 (3.3, 4.8)

4.0 (3.3, 4.8)

Unadjusted Calcium*

2.21 (2.05, 2.39)

2.21 (2.05, 2.39)

2.23 (2.06, 2.41)

PO4 (mM)

All patients

1.79 (1.40, 2.24)

1.79 (1.4,0 2.24)

1.77 (1.38, 2.21)

> = 3 x week RRT

1.74 (1.37, 2.20)

1.75 (1.36, 2.20)

1.75 (1.38, 2

> = 3 x week RRT & Kt/V > =1.2

1.76 (1.38, 2.2)

1.76 (1.37, 2.2)

1.77 (1.39, 2.22)

Frequency of RRT*

< 3 x week

2721 (29%)

2525 (35%)

196 (9%)

> = 3 x week RRT

6630 (71%)

4682 (65%)

1948 (91%)

Kt/V

All patients*

1.29 (1.08, 1.53)

1.31 (1.10, 1.54)

1.24 (1.03, 1.47)

> = 3 x week RRT*

1.26 (1.05, 1.48)

1.27 (1.06, 1.49)

1.24 (1.02, 1.47)

IDWG (% of weight)

All patients*

3.3 (2.0, 4.5)

3.4 (2.1, 4.6)

3.1 (1.7, 4.2)

> = 3 x week RRT*

3.2 (1.8, 4.3)

3.2 (1.9, 4.4)

3 (1.7, 4.2)

Hemoperfusion*

165 (2%)

27 (0.5%)

138 (6%)

Vascular access*

AVF/AVG

4925 (53%)

3745 (52%)

1179 (55%)

CVC / Other

4426 (47%)

3461 (48%)

965 (45%)