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Table 4 Mean follow-up time, total numbers of events, and crude event rates of renal and atherosclerotic cardiovascular composite endpoints and all-cause mortality by quartile of HOMA-IR among CRIC participants without diabetes at baseline

From: Insulin resistance and chronic kidney disease progression, cardiovascular events, and death: findings from the chronic renal insufficiency cohort study

  Quartile of HOMA-IR
  Overall Quartile 1 Quartile 2 Quartile 3 Quartile 4a Quartile 4b
Event: Composite Renal Endpoint (ESRD/Halving of eGFR)
 Sample size 1883 471 471 471 235 235
 # of events 474 114 109 126 64 61
 Median (IQR) follow up, years 7.76 (3.40–10.26) 7.65 (3.06–10.30) 7.88 (3.24–10.35) 7.76 (3.93–10.18) 7.30 (3.57–10.03) 7.84 (3.32–10.16)
 Event rate per 100 person-years (95% CI) 3.68 (3.37–4.03) 3.55 (2.96–4.27) 3.39 (2.81–4.09) 3.85 (3.23–4.58) 4.08 (3.20–4.58) 3.80 (2.96–4.88)
Event: Composite Atherosclerotic CVD Endpoint (MI/PAD/stroke)
 Sample size 1883 471 471 471 235 235
 # of events 220 47 53 55 33 32
 Median (IQR) follow up, years 9.43 (5.95–10.81) 9.41 (6.14–10.90) 9.51 (5.86–10.70) 9.45 (7.03–10.87) 9.51 (6.10–10.70) 9.23 (5.43–10.59)
 Event rate per 100 person-years (95% CI) 1.43 (1.25–1.63) 1.22 (0.92–1.62) 1.38 (1.05–1.80) 1.39 (1.07–1.82) 1.73 (1.23–2.43) 1.72 (1.22–2.44)
Event: All-Cause Mortality
 Sample size 1883 471 471 471 235 235
 # of events 379 96 90 98 44 51
 Median (IQR) follow up, years 10.15 (8.74–11.09) 10.18 (8.66–11.10) 10.00 (8.66–11.02) 10.25 (8.83–11.14) 10.21 (8.98–11.05) 9.74 (8.60–11.01)
 Event rate per 100 person-years (95% CI) 2.19 (1.98–2.42) 2.21 (1.81–2.71) 2.11 (1.72–2.60) 2.23 (1.83–2.72) 2.00 (1.49–2.69) 2.40 (1.83–3.16)
  1. Abbreviations: CVD – cardiovascular disease, eGFR – estimated glomerular filtration rate, ESRD – end-stage renal disease, HOMA-IR – homeostasis model assessment insulin resistance, IQR – interquartile range, MI – myocardial infarction, PAD – peripheral arterial disease, CI- confidence interval