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Table 4 Mean follow-up time, total numbers of events, and crude event rates of renal and atherosclerotic cardiovascular composite endpoints and all-cause mortality by quartile of HOMA-IR among CRIC participants without diabetes at baseline

From: Insulin resistance and chronic kidney disease progression, cardiovascular events, and death: findings from the chronic renal insufficiency cohort study

 

Quartile of HOMA-IR

 

Overall

Quartile 1

Quartile 2

Quartile 3

Quartile 4a

Quartile 4b

Event: Composite Renal Endpoint (ESRD/Halving of eGFR)

 Sample size

1883

471

471

471

235

235

 # of events

474

114

109

126

64

61

 Median (IQR) follow up, years

7.76 (3.40–10.26)

7.65 (3.06–10.30)

7.88 (3.24–10.35)

7.76 (3.93–10.18)

7.30 (3.57–10.03)

7.84 (3.32–10.16)

 Event rate per 100 person-years (95% CI)

3.68 (3.37–4.03)

3.55 (2.96–4.27)

3.39 (2.81–4.09)

3.85 (3.23–4.58)

4.08 (3.20–4.58)

3.80 (2.96–4.88)

Event: Composite Atherosclerotic CVD Endpoint (MI/PAD/stroke)

 Sample size

1883

471

471

471

235

235

 # of events

220

47

53

55

33

32

 Median (IQR) follow up, years

9.43 (5.95–10.81)

9.41 (6.14–10.90)

9.51 (5.86–10.70)

9.45 (7.03–10.87)

9.51 (6.10–10.70)

9.23 (5.43–10.59)

 Event rate per 100 person-years (95% CI)

1.43 (1.25–1.63)

1.22 (0.92–1.62)

1.38 (1.05–1.80)

1.39 (1.07–1.82)

1.73 (1.23–2.43)

1.72 (1.22–2.44)

Event: All-Cause Mortality

 Sample size

1883

471

471

471

235

235

 # of events

379

96

90

98

44

51

 Median (IQR) follow up, years

10.15 (8.74–11.09)

10.18 (8.66–11.10)

10.00 (8.66–11.02)

10.25 (8.83–11.14)

10.21 (8.98–11.05)

9.74 (8.60–11.01)

 Event rate per 100 person-years (95% CI)

2.19 (1.98–2.42)

2.21 (1.81–2.71)

2.11 (1.72–2.60)

2.23 (1.83–2.72)

2.00 (1.49–2.69)

2.40 (1.83–3.16)

  1. Abbreviations: CVD – cardiovascular disease, eGFR – estimated glomerular filtration rate, ESRD – end-stage renal disease, HOMA-IR – homeostasis model assessment insulin resistance, IQR – interquartile range, MI – myocardial infarction, PAD – peripheral arterial disease, CI- confidence interval