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Table 1 Comparison of clinical and laboratory parameters between expanded criteria donor (or recipient) and standard criteria donor (or recipient)

From: Impact of acute kidney injury in expanded criteria deceased donors on post-transplant clinical outcomes: multicenter cohort study

Variables

SCD (n = 278)

ECD (n = 108)

p for Trend

Donors

 Age at KT (years)

38.9 ± 13.4

58.4 ± 5.2

< 0.001

 Gender (Male: Female)

188: 90

79: 29

0.327

 BMI (kg/m2)

22.7 ± 3.8

23.2 ± 2.7

0.153

 HTN, n (%)

36 (13.4)

50 (47.6)

< 0.001

 DM, n (%)

15 (5.5)

19 (18.1)

< 0.001

 Cause of donor death - CVA, n (%)

202 (72.7)

89 (82.4)

0.049

 Baseline eGFR (ml/min/1.73 m2)

76.0 ± 44.9

58.8 ± 23.6

< 0.001

 CKD stage 3 or above stage, n (%)

137 (49.5)

68 (63.0)

0.017

  AKI, n (%)

112 (40.3)

81 (75.0)

< 0.001

  Stage 1

43 (38.4)

22 (27.2)

 

  Stage 2

32 (28.6)

28 (34.6)

 

  Stage 3

37 (33.0)

31 (38.3)

 
 

SCD-KT (n = 350)

ECD-KT (n = 159)

p for Trend

Recipients

 Transplant centers, n (%)

  

0.083

  A

256 (73.1)

122 (76.7)

 

  B

21 (6.0)

15 (9.4)

 

  C

73 (20.9)

22 (13.8)

 

 Transplant year, n (%)

  

0.005

  1996–2005

35 (10.2)

6 (3.8)

 

  2006–2010

74 (21.1)

21 (13.2)

 

  2011–2016

241 (68.9)

132 (83.0)

 

 Age at KT (year)

46.6 ± 10.1

51.1 ± 9.4

< 0.001

 Gender (Male: Female)

191: 159

100: 59

0.083

 BMI (kg/m2)

22.5 ± 3.1

23.4 ± 3.4

0.003

 HTN, n (%)

297 (84.9)

139 (87.4)

0.497

 DM, n (%)

55 (15.7)

43 (27.0)

0.004

 Dialysis before KT, n (%)

344 (98.3)

158 (99.4)

0.443

 Dialysis duration, years

7.3 ± 4.6

7.6 ± 13.0

0.801

 Previous KT, n (%)

41 (11.7)

10 (6.3)

0.079

 Cause of ESRD, n (%)

  

0.001

  Glomerulonephritis

165 (47.1)

53 (33.3)

 

  DM

45 (12.9)

36 (22.6)

 

  HTN

57 (16.3)

40 (25.2)

 

  Others

83 (23.7)

30 (18.9)

 

 Cold ischemic time (min)

244 ± 131

240 ± 110

0.749

 HLA mismatch number

3.7 ± 1.4

3.7 ± 1.5

0.646

 Induction, n (%)

  

0.070

  Basiliximab

279 (79.7)

114 (71.7)

 

  ATG

70 (20.0)

45 (28.3)

 

 Main immunosuppressant, n (%)

  Tacrolimus: Cyclosporine

316: 33

153: 6

0.035

 PRA > 50%

52 (18.6)

20 (13.7)

0.222

  1. Values are expressed as means ± SDs, or n (%)
  2. SCD standard criteria donor, ECD expanded criteria donor, KT kidney transplantation, BMI body mass index, HTN hypertension, DM diabetes mellitus, CVA cerebrovascular accident, eGFR estimated glomerular filtration rate, CKD chronic kidney disease, AKI acute kidney injury, ESRD end-stage renal disease, HLA human leukocyte antigen, ATG antithymocyte globulin, PRA panel reactive antibody