| Total patients n = 174 | Low CAC (≤ 100 AUs) (n = 70) | High CAC (>100 AUs) (n = 104) | P value |
---|---|---|---|---|
Demography and metabolic biomarkers | ||||
 Age, years | 57 (29, 75) | 41 (23, 63) | 64 (49, 78) | < 0.001 |
 Male, % | 63 | 57 | 67 | 0.173 |
 Diabetes, % | 28 | 10 | 40 | < 0.001 |
 CVD, % | 22 | 3 | 36 | < 0.001 |
 Body mass index, kg/m2 | 24.8 (19.9, 30.8) | 23.9 (19.7, 30.7) | 25.2 (20.7, 30.8) | 0.080 |
 Systolic BP, mmHg | 139 (114, 169) | 135 (114, 163) | 143 (113, 179) | 0.024 |
 Diastolic BP, mmHg | 83 (67, 97) | 85 (70, 100) | 81 (66, 96) | 0.123 |
 Hemoglobin, g/L | 114 (94, 130) | 113 (92, 128) | 114 (100, 130) | 0.064 |
 Triglycerides, mmol/L | 1.6 (0.9, 3.0) | 1.6 (0.9, 2.8) | 1.4 (0.9, 3.6) | 0.039 |
 Cholesterol, mmol/L | 4.7 (3.3, 6.6) | 4.6 (3.4, 6.1) | 4.6 (3.0, 5.7) | 0.175 |
 HDL-cholesterol, mmol/L | 1.2 (0.8, 2.3) | 1.4 (0.9, 2.4) | 1.1 (0.9, 2.3) | 0.373 |
 Creatinine, μmol/L | 727 (491, 1012) | 738 (509, 1185) | 729 (414, 981) | 0.014 |
 S-albumin, g/L | 33 (26, 39) | 35 (28, 40) | 32 (23, 38) | 0.001 |
 hsCRP, mg/L | 2.1 (0.4, 18.7) | 1.2 (0.2, 9.1) | 3.6 (0.8, 35.4) | 0.003 |
 TNF, pg/ml a | 15.3 (9.9, 20.4) | 12.9 (8.0, 19.8) | 16.7 (12.0, 20.7) | 0.003 |
 IL-6, pg/ml b | 4.5 (0.9, 14.9) | 2.1 (0.4, 8.1) | 6.9 (2.2, 20.5) | < 0.001 |
 PTX3 ng/mL c | 1.7 (0.7, 6.2) | 1.8 (0.6, 7.1) | 1.7 (0.7, 7.1) | 0.758 |
 Total testosterone in male, nmol/Ld | 11.0 (5.8, 20.5) | 12.2 (7.4, 25.6) | 10.2 (4.7, 16.9) | 0.025 |
Mineral bone disease biomarkers | ||||
 iPTH, ng/L | 300 (96, 655) | 265 (113, 658) | 320 (79, 735) | 0.595 |
 Calcium, mmol/L | 2.3 (2.0, 2.5) | 2.3 (2.1, 2.5) | 2.2 (1.9, 2.6) | 0.924 |
 Phosphate, mmol/L | 1.8 (1.2, 2.5) | 1.9 (1.2, 2.4) | 1.8 (1.2, 2.6) | 0.559 |
 1,25-OH vitamin D, nmol/L e | 13 (9, 28) | 16.5 (9, 34) | 11 (9, 23) | 0.054 |
 25-OH vitamin D, ng/L f | 29 (13, 70) | 33 (14, 57) | 29 (14, 80) | 0.861 |
 tBMD, g/cm2 | 1.12 (0.92, 1.30) | 1.13 (1.00, 1.31) | 1.10 (0.91, 1.27) | 0.095 |
 T-score of tBMD | −0.8 (−2.7, 1.1) | − 0.6 (− 2.0, 1.2) | −1.1 (− 3.1, 1.1) | 0.006 |
 Z-score of tBMD | − 0.4 (− 1.8, 1.2) | − 0.1 (− 1.5, 1.1) | − 0.5 (− 2.4, 1.3) | 0.097 |