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Table 1 Clinical and biochemical characteristics for the total 174 ESRD patients and for two subgroups based according to CAC score

From: Differences in association of lower bone mineral density with higher coronary calcification in female and male end-stage renal disease patients

 

Total patients

n = 174

Low CAC

(≤ 100 AUs)

(n = 70)

High CAC

(>100 AUs)

(n = 104)

P value

Demography and metabolic biomarkers

 Age, years

57 (29, 75)

41 (23, 63)

64 (49, 78)

< 0.001

 Male, %

63

57

67

0.173

 Diabetes, %

28

10

40

< 0.001

 CVD, %

22

3

36

< 0.001

 Body mass index, kg/m2

24.8 (19.9, 30.8)

23.9 (19.7, 30.7)

25.2 (20.7, 30.8)

0.080

 Systolic BP, mmHg

139 (114, 169)

135 (114, 163)

143 (113, 179)

0.024

 Diastolic BP, mmHg

83 (67, 97)

85 (70, 100)

81 (66, 96)

0.123

 Hemoglobin, g/L

114 (94, 130)

113 (92, 128)

114 (100, 130)

0.064

 Triglycerides, mmol/L

1.6 (0.9, 3.0)

1.6 (0.9, 2.8)

1.4 (0.9, 3.6)

0.039

 Cholesterol, mmol/L

4.7 (3.3, 6.6)

4.6 (3.4, 6.1)

4.6 (3.0, 5.7)

0.175

 HDL-cholesterol, mmol/L

1.2 (0.8, 2.3)

1.4 (0.9, 2.4)

1.1 (0.9, 2.3)

0.373

 Creatinine, μmol/L

727 (491, 1012)

738 (509, 1185)

729 (414, 981)

0.014

 S-albumin, g/L

33 (26, 39)

35 (28, 40)

32 (23, 38)

0.001

 hsCRP, mg/L

2.1 (0.4, 18.7)

1.2 (0.2, 9.1)

3.6 (0.8, 35.4)

0.003

 TNF, pg/ml a

15.3 (9.9, 20.4)

12.9 (8.0, 19.8)

16.7 (12.0, 20.7)

0.003

 IL-6, pg/ml b

4.5 (0.9, 14.9)

2.1 (0.4, 8.1)

6.9 (2.2, 20.5)

< 0.001

 PTX3 ng/mL c

1.7 (0.7, 6.2)

1.8 (0.6, 7.1)

1.7 (0.7, 7.1)

0.758

 Total testosterone in male, nmol/Ld

11.0 (5.8, 20.5)

12.2 (7.4, 25.6)

10.2 (4.7, 16.9)

0.025

Mineral bone disease biomarkers

 iPTH, ng/L

300 (96, 655)

265 (113, 658)

320 (79, 735)

0.595

 Calcium, mmol/L

2.3 (2.0, 2.5)

2.3 (2.1, 2.5)

2.2 (1.9, 2.6)

0.924

 Phosphate, mmol/L

1.8 (1.2, 2.5)

1.9 (1.2, 2.4)

1.8 (1.2, 2.6)

0.559

 1,25-OH vitamin D, nmol/L e

13 (9, 28)

16.5 (9, 34)

11 (9, 23)

0.054

 25-OH vitamin D, ng/L f

29 (13, 70)

33 (14, 57)

29 (14, 80)

0.861

 tBMD, g/cm2

1.12 (0.92, 1.30)

1.13 (1.00, 1.31)

1.10 (0.91, 1.27)

0.095

 T-score of tBMD

−0.8 (−2.7, 1.1)

− 0.6 (− 2.0, 1.2)

−1.1 (− 3.1, 1.1)

0.006

 Z-score of tBMD

− 0.4 (− 1.8, 1.2)

− 0.1 (− 1.5, 1.1)

− 0.5 (− 2.4, 1.3)

0.097

  1. Data presented as median (range of 10th - 90th percentile) or percentage
  2. Abbreviations: BP blood pressure, HDL high-density lipoprotein, hsCRP high sensitivity C-reactive protein, TNF tumor necrosis factor, IL-6 interleukin-6, PTX pentraxin, iPTH intact parathyroid hormone, CAC coronary artery calcification, tBMD total bone mineral density
  3. an = 151, bn = 166, cn = 135; dn = 95; en = 130, fn = 105