Table 1 Demographic, clinical, laboratory values and mortality in total serum IS and according to the 2 a priori-selected groups of serum IS levels in 262 patients at the time of AKI diagnosis
|  | Total n = 262 | IS < 2.74 μg/ml n = 131 | IS ≥ 2.74 μg/ml n = 131 | P |
|---|---|---|---|---|
In-hospital mortality, n % | 73 (27.9) | 26 (19.8) | 47 (35.9) | 0.004 |
90d mortality, n % | 94 (35.9) | 38 (29.0) | 56 (42.7) | 0.019 |
Demographic | ||||
 Age, yr | 62.6 ± 16.6 | 64.04 ± 15.29 | 61.11 ± 17.78 | 0.154 |
 Male, n % | 195 (74.4) | 96 (73.3) | 99 (75.6) | 0.389 |
 MAP, mmHg | 85.3 (73.3, 96.7) | 86.7 (74.8, 98.5) | 84.2 (68.5, 94.5) | 0.073 |
Comorbid conditions, n % | ||||
 Hypertension | 102 (38.9) | 51 (38.9) | 51 (38.9) | 0.550 |
 Coronary heart disease | 42 (16.0) | 24 (18.3) | 18 (13.7) | 0.312 |
 Diabetes mellitus | 46 (17.5) | 29 (22.1) | 17 (13.0) | 0.037 |
 Chronic hepatic disease | 13 (5.0) | 8 (6.1) | 5 (3.8) | 0.286 |
 Chronic kidney disease | 20 (7) | 7 (5.3) | 13 (9.9) | 0.122 |
 Surgery | 187 (71.4) | 81 (61.8) | 106 (80.9) | < 0.001 |
 Sepsis | 76 (29.0) | 33 (25.2) | 43 (32.8) | 0.110 |
AKI stage at diagnosis, n % | ||||
 1 | 119 (45.5) | 64 (48.9) | 55 (42.0) | 0.264 |
 2 | 63 (24.0) | 29 (22.1) | 34 (26.0) | 0.470 |
 3 | 80 (30.5) | 38 (29.0) | 42 (32.0) | 0.591 |
 RRT, n % | 40 (15.3) | 13 (9.9) | 27 (20.6) | 0.016 |
 Mechanical ventilation, n % | 96 (36.6) | 42 (32.1) | 54 (41.2) | 0.079 |
 APACHE II score | 18.4 ± 8.7 | 17.5 ± 8.6 | 19.4 ± 8.9 | 0.117 |
Biochemical measurements | ||||
Serum | ||||
 Creatinine, μmol/L | 167 (137,226) | 153 (132,195) | 177 (146,265) | 0.001 |
 Urea nitrogen, mmol/L | 15 (11.1,21.9) | 13.9 (9.5,20.6) | 17.1 (12.5,25.1) | 0.001 |
 β2-microglobulin, mg/L | 5.1 (3.6,8.2) | 4.3 (2.9, 6.6) | 6.3 (4.2, 8.6) | 0.001 |
 Albumin, g/L | 32.7 ± 7.1 | 32.8 ± 7.3 | 29.2 ± 7.6 | 0.095 |
 Cholesterol, mmol/L | 6.3 (4.1, 10.1) | 7.5 (4.6,11.4) | 5.1 (3.9, 8.8) | 0.063 |
 ALT, IU/L | 31.5 (19.0,62.8) | 27.0 (19.0, 57.8) | 35.0 (19.3, 70.8) | 0.186 |
 hsCRP, mg/L | 95.3 ± 76.3 | 85.6 ± 81.5 | 107.4 ± 68.0 | 0.095 |
Blood | ||||
 WBC counts, × 109 cell/L | 13.4 ± 6.8 | 13.1 ± 8.0 | 13.8 ± 5.4 | 0.389 |
 Neutrophilic granulocyte, % | 79.4 (16.2,86.9) | 79.9 (17.4,85.8) | 77.9 (14.8,88.1) | 0.588 |
 RBC counts, × 1012 cell/L | 3.6 ± 0.8 | 3.5 ± 0.8 | 3.7 ± 0.9 | 0.045 |
 Hemoglobin, g/L | 108.3 ± 24.0 | 104.6 ± 21.5 | 112.0 ± 25.9 | 0.013 |
 Platelet counts, ×1012/L | 150.4 ± 92.1 | 160.1 ± 100.0 | 140.5 ± 82.4 | 0.085 |