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Table 2 Multivariate Cox proportional hazard model of mortality during 90-day follow-up in AKI patients (IS entered as a continuous or dichotomous variable)

From: Serum indoxyl sulfate is associated with mortality in hospital-acquired acute kidney injury: a prospective cohort study

Model HR 95% CI P
IS (continuous variable)
 Unadjusted 1.47 1.12–1.93 0.006
 Model 1 1.48 1.11–1.96 0.007
 Model 2 1.51 1.15–2.00 0.003
 Model 3 1.47 1.11–1.97 0.008
 Model 4 1.61 1.19–2.17 0.002
 Model 5 1.74 1.27–2.39 0.001
IS (dichotomous variable)
 Unadjusted 1.75 1.16–2.64 0.008
 Model 1 1.75 1.18–2.70 0.006
 Model 2 2.01 1.30–3.10 0.002
 Model 3 2.00 1.28–3.14 0.002
 Model 4 2.47 1.53–3.98 < 0.001
 Model 5 2.92 1.76–4.86 < 0.001
  1. Variables of model 1 include age and gender
  2. Variables of model 2 include age, gender, non-renal APACHE II score, sepsis, RRT, and surgery
  3. Variables of model 3 include age, gender, non-renal APACHE II score, sepsis, RRT, surgery, serum albumin, creatinine, BUN and β2-microglobulin
  4. Variables of model 4 include age, gender, non-renal APACHE II score, sepsis, RRT, surgery, serum albumin, creatinine, BUN, β2-microglobulin, ALT, neutrophilic granulocyte and platelet counts
  5. Variables of model 5 include age, gender, non-renal APACHE II score, sepsis, RRT, surgery, serum albumin, creatinine, BUN, β2-microglobulin, ALT, neutrophilic granulocyte, platelet counts, and interaction terms (gender*platelet counts, surgery*serum albumin, surgery*creatinine and ALT*platelet counts)
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