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Table 2 Multivariate Cox proportional hazard model of mortality during 90-day follow-up in AKI patients (IS entered as a continuous or dichotomous variable)

From: Serum indoxyl sulfate is associated with mortality in hospital-acquired acute kidney injury: a prospective cohort study

Model

HR

95% CI

P

IS (continuous variable)

 Unadjusted

1.47

1.12–1.93

0.006

 Model 1

1.48

1.11–1.96

0.007

 Model 2

1.51

1.15–2.00

0.003

 Model 3

1.47

1.11–1.97

0.008

 Model 4

1.61

1.19–2.17

0.002

 Model 5

1.74

1.27–2.39

0.001

IS (dichotomous variable)

 Unadjusted

1.75

1.16–2.64

0.008

 Model 1

1.75

1.18–2.70

0.006

 Model 2

2.01

1.30–3.10

0.002

 Model 3

2.00

1.28–3.14

0.002

 Model 4

2.47

1.53–3.98

< 0.001

 Model 5

2.92

1.76–4.86

< 0.001

  1. Variables of model 1 include age and gender
  2. Variables of model 2 include age, gender, non-renal APACHE II score, sepsis, RRT, and surgery
  3. Variables of model 3 include age, gender, non-renal APACHE II score, sepsis, RRT, surgery, serum albumin, creatinine, BUN and β2-microglobulin
  4. Variables of model 4 include age, gender, non-renal APACHE II score, sepsis, RRT, surgery, serum albumin, creatinine, BUN, β2-microglobulin, ALT, neutrophilic granulocyte and platelet counts
  5. Variables of model 5 include age, gender, non-renal APACHE II score, sepsis, RRT, surgery, serum albumin, creatinine, BUN, β2-microglobulin, ALT, neutrophilic granulocyte, platelet counts, and interaction terms (gender*platelet counts, surgery*serum albumin, surgery*creatinine and ALT*platelet counts)