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Table 4 Multivariate Cox proportional hazard model of mortality during 90-day follow-up in AKI patients (serum creatinine entered as a continuous or dichotomous variable)

From: Serum indoxyl sulfate is associated with mortality in hospital-acquired acute kidney injury: a prospective cohort study

Model HR 95% CI P
Serum creatinine (continuous variable)
 Unadjusted 1.00 1.00–1.00 0.002
 Model 1 1.00 1.00–1.00 0.002
 Model 2 1.00 1.00–1.00 0.696
 Model 3 1.00 1.00–1.00 0.597
 Model 4 1.00 1.00–1.00 0.924
 Model 5 1.00 1.00–1.00 0.360
Serum creatinine (dichotomous variable)
 Unadjusted 2.02 1.32–3.07 0.001
 Model 1 1.96 1.28–2.99 0.002
 Model 2 1.07 0.68–1.68 0.762
 Model 3 0.87 0.54–1.42 0.583
 Model 4 1.14 0.69–1.88 0.608
 Model 5 0.93 0.55–1.57 0.791
  1. Variables of model 1 include age and gender
  2. Variables of model 2 include age, gender, non-renal APACHE II score, sepsis, RRT, and surgery
  3. Variables of model 3 include age, gender, non-renal APACHE II score, sepsis, RRT, surgery, serum albumin, IS, BUN and β2-microglobulin
  4. Variables of model 4 include age, gender, non-renal APACHE II score, sepsis, RRT, surgery, serum albumin, IS, BUN, β2-microglobulin, ALT, neutrophilic granulocyte and platelet counts
  5. Variables of model 5 include age, gender, non-renal APACHE II score, sepsis, RRT, surgery, serum albumin, IS, BUN, β2-microglobulin, ALT, neutrophilic granulocyte, platelet counts and interaction terms (gender*platelet counts, surgery*serum albumin, surgery*creatinine, and ALT*platelet counts)