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Table 1 Clinical parameters of chronic kidney disease (CKD) rats

From: DPP-4 inhibition enhanced renal tubular and myocardial GLP-1 receptor expression decreased in CKD with myocardial infarction

  Control CKD 2 wks CKD 4 wks CKD 8 wks
Body Weight (g) 430.8 ± 18.4 319.4 ± 26.1** 334.5 ± 0.7** 371.3 ± 47.5*
24 Hr urine volume (mL) 14.8 ± 5.1 32.4 ± 10.0** 32.0 ± 0.0** 43.0 ± 12.3**
Urine pH 7.19 ± 0.50 7.38 ± 0.35 8.85 ± 0.04** †† 7.35 ± 0.13‡‡
Systolic blood pressure (mmHg) 78.0 ± 9.8 137.4 ± 10.0** 138.5 ± 10.0** 141.0 ± 7.5**
Glucose (mg/dL) 453.3 ± 56.9 277.5 ± 37.5* 299.5 ± 2.1* 298.3 ± 44.8*
Serum Cr (mg/dL) 0.28 ± 0.02 1.55 ± 0.09** 1.52 ± 0.06** 1.59 ± 0.10**
BUN (mg/dL) 19.3 ± 4.5 41.7 ± 7.8 43.3 ± 4.9* 42.3 ± 5.6*
Serum albumin (mg/dL) 2.1 ± 0.1 1.2 ± 0.1* 1.4 ± 0.1* 1.2 ± 0.1**
ClCr (ml/min/100 g) 0.60 ± 0.06 0.07 ± 0.01** 0.08 ± 0.04* 0.09 ± 0.03**
  1. Cr Creatinine, BUN Blood urea nitrogen, ClCr Creatinine clearance, Control Sham-operated, CKD 2, 4, 8 weeks. Values are presented as the mean ± standard deviation (SD). n = number of rats. *p < 0.05 vs. control, **p < 0.01 vs. control