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Table 1 Clinical parameters of chronic kidney disease (CKD) rats

From: DPP-4 inhibition enhanced renal tubular and myocardial GLP-1 receptor expression decreased in CKD with myocardial infarction

 

Control

CKD 2 wks

CKD 4 wks

CKD 8 wks

Body Weight (g)

430.8 ± 18.4

319.4 ± 26.1**

334.5 ± 0.7**

371.3 ± 47.5*

24 Hr urine volume (mL)

14.8 ± 5.1

32.4 ± 10.0**

32.0 ± 0.0**

43.0 ± 12.3**

Urine pH

7.19 ± 0.50

7.38 ± 0.35

8.85 ± 0.04** ††

7.35 ± 0.13‡‡

Systolic blood pressure (mmHg)

78.0 ± 9.8

137.4 ± 10.0**

138.5 ± 10.0**

141.0 ± 7.5**

Glucose (mg/dL)

453.3 ± 56.9

277.5 ± 37.5*

299.5 ± 2.1*

298.3 ± 44.8*

Serum Cr (mg/dL)

0.28 ± 0.02

1.55 ± 0.09**

1.52 ± 0.06**

1.59 ± 0.10**

BUN (mg/dL)

19.3 ± 4.5

41.7 ± 7.8

43.3 ± 4.9*

42.3 ± 5.6*

Serum albumin (mg/dL)

2.1 ± 0.1

1.2 ± 0.1*

1.4 ± 0.1*

1.2 ± 0.1**

ClCr (ml/min/100 g)

0.60 ± 0.06

0.07 ± 0.01**

0.08 ± 0.04*

0.09 ± 0.03**

  1. Cr Creatinine, BUN Blood urea nitrogen, ClCr Creatinine clearance, Control Sham-operated, CKD 2, 4, 8 weeks. Values are presented as the mean ± standard deviation (SD). n = number of rats. *p < 0.05 vs. control, **p < 0.01 vs. control