| |
Control
|
CKD 2 wks
|
CKD 4 wks
|
CKD 8 wks
|
|---|
|
Body Weight (g)
|
430.8 ± 18.4
|
319.4 ± 26.1**
|
334.5 ± 0.7**
|
371.3 ± 47.5*
|
|
24 Hr urine volume (mL)
|
14.8 ± 5.1
|
32.4 ± 10.0**
|
32.0 ± 0.0**
|
43.0 ± 12.3**
|
|
Urine pH
|
7.19 ± 0.50
|
7.38 ± 0.35
|
8.85 ± 0.04** ††
|
7.35 ± 0.13‡‡
|
|
Systolic blood pressure (mmHg)
|
78.0 ± 9.8
|
137.4 ± 10.0**
|
138.5 ± 10.0**
|
141.0 ± 7.5**
|
|
Glucose (mg/dL)
|
453.3 ± 56.9
|
277.5 ± 37.5*
|
299.5 ± 2.1*
|
298.3 ± 44.8*
|
|
Serum Cr (mg/dL)
|
0.28 ± 0.02
|
1.55 ± 0.09**
|
1.52 ± 0.06**
|
1.59 ± 0.10**
|
|
BUN (mg/dL)
|
19.3 ± 4.5
|
41.7 ± 7.8
|
43.3 ± 4.9*
|
42.3 ± 5.6*
|
|
Serum albumin (mg/dL)
|
2.1 ± 0.1
|
1.2 ± 0.1*
|
1.4 ± 0.1*
|
1.2 ± 0.1**
|
|
ClCr (ml/min/100 g)
|
0.60 ± 0.06
|
0.07 ± 0.01**
|
0.08 ± 0.04*
|
0.09 ± 0.03**
|
- Cr Creatinine, BUN Blood urea nitrogen, ClCr Creatinine clearance, Control Sham-operated, CKD 2, 4, 8 weeks. Values are presented as the mean ± standard deviation (SD). n = number of rats. *p < 0.05 vs. control, **p < 0.01 vs. control
