Post renal transplant anemia: severity, causes and their association with graft and patient survival

BMC Nephrology

Table 4 Death censored graft failure

		Univariate			Multivariate
		HR	95% CI	P value	HR	95% CI	P value
Presence of anemia	Early	4.06	2.17–7.57	< 0.001	3.15	1.63–6.08	0.001
Presence of anemia	Late	2.17	1.33–3.55	0.002	1.853	1.09–3.16	0.024
Severity of anemia
Mild (Hb > 11 g/dL)	Early	1.76	0.77–4.03	0.179	1.35	0.56–3.25	0.5
Mild (Hb > 11 g/dL)	Late	2	1.14–3.5	0.015	1.66	0.91–3.01	0.096
Severe (Hb < 11 g/dL)	Early	9.78	5.0–19.13	< 0.001	7.6	3.69–15.65	< 0.001
Severe (Hb < 11 g/dL)	Late	2.65	1.25–5.64	0.011	2.61	1.15–5.92	0.021
Causes of anemia
Acute rejection and/or acute kidney injury	Early	18.18	9.15–32.32	< 0.001	12.94	6.14–27.28	< 0.001
Acute rejection and/or acute kidney injury	Late	3.93	1.68–9.29	0.002	4.14	1.64–10.45	0.003
Infection	Early	3.47	1.15–10.47	0.027	3.01	0.97–9.33	0.056
Infection	Late	1.36	0.42–4.39	0.603	1.09	0.33–3.64	0.885
Nutritional deficiencies	Early	3.25	0.74–14.14	0.117	1.63	0.21–12.51	0.636
Nutritional deficiencies	Late	1.47	0.2–10.75	0.703	1.88	0.25–14.13	0.538
Miscellaneous	Early	2.75	1.07–7.1	0.036	2.14	0.81–5.65	0.125
Miscellaneous	Late	2.57	1.2–5.49	0.015	1.91	0.86–4.23	0.11
No reason found	Early^a
No reason found	Late	1.75	0.79-3.88	0.17	1.58	0.69–3.64	0.28

Abbreviations: HR Hazard ratio, CI Confidence interval
Covariates included in the multivariate models are specified in the supplementary tables
^aNo outcome events

ISSN: 1471-2369