Table 3 Plasma metabolites significantly (p < 0.05) associated with baseline ht-TKV. Effect size represents the magnitude and direction (+/−) of association between a given metabolite and ht-TKV, estimated by linear regression, while controlling for the selected HALT covariates, age, sex, genotype, site of sample collection, and BMI
Metabolite | Effect Size (SD) | p-value | FDR q-value | KEGG ID | PubChem ID |
|---|---|---|---|---|---|
pseudo uridine | 0.2273 (0.082) | 0.0061 | 0.3375 | C02067 | 15,047 |
aminomalonate | 0.1240 (0.047) | 0.0094 | 0.3375 | C00872 | 100,714 |
Taurine | −0.0577 (0.024) | 0.0151 | 0.3375 | C00245 | 1123 |
Tyrosine | −0.1984 (0.082) | 0.0156 | 0.3375 | C00082 | 6057 |
isothreonic acid | 0.1333 (0.055) | 0.0166 | 0.3375 | C21649 | 151,152 |
glutamic acid | −0.1111 (0.048) | 0.0217 | 0.3677 | C00025 | 33,032 |
indole-3-lactate | 0.1544 (0.070) | 0.0273 | 0.3965 | C02043 | 92,904 |
myo-inositol | 0.1080 (0.052) | 0.0373 | 0.4075 | C00137 | 892 |
2-hydroxybutanoic acid | −0.0940 (0.045) | 0.0384 | 0.4075 | C05984 | 440,864 |
Beta-D-fucose | 0.0913 (0.046) | 0.0482 | 0.4075 | C02095 | 439,650 |