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Table 4 Project patient-years gained based on relative risk for compliance with recommended targets (over 5 years)

From: Potential life-years gained over a 5-year period by correcting DOPPS-identified modifiable practices in haemodialysis: results from the European MONITOR-CKD5 study

Measure Current statistics Kt/V ≥ 1.2 Phosphate ≤ 5.5 mg/dL Hb ≥ 10 g/dL IDWG ≤ 5.7% Albumin  ≥ 4.0 g/dl AVF or graft v. catheter All 6 Factors
Annual death rate 0.150 1 0.1467 2 0.1423 2 0.1455 2 0.1475 2 0.1189 2 0.1424 2 0.1173 2
Annual rate of other loss3 0.053 0.053 0.053 0.053 0.053 0.053 0.053 0.053
L (Total loss rate) 0.203 0.200 0.195 0.199 0.200 0.172 0.195 0.170
T 5 5 5 5 5 5 5 5
N0 4 303,517 303,517 303,517 303,517 303,517 303,517 303,517 303,517
N1 5 66,597 66,597 66,597 66,597 66,597 66,597 66,597 66,597
FD 0.63760 0.63164 0.62343 0.62938 0.63298 0.57668 0.62363 0.57321
PY 1,563,221 1,572,540 1,585,273 1,576,047 1,570,443 1,655,565 1,584,967 1,660,650
Potential patient years gained         
if 100% brought within target   9319 22,052 12,826 7222 92,344 21,746 97,4296
if 50% brought within target7   4501 10,651 6195 3488 44,601 10,503 47,057
  1. Hb haemoglobin, IDWG inter-dialytic weight gain, AVF arterio-venous fistula, L annual rate of US haemodialysis patients lost from the haemodialysis population due to death or transfer to transplantation or peritoneal dialysis, t total time period, N0 number of patients prevalent at the start of the 5-year time interval, N1 number of incident patients entering the haemodialysis patient population during each year, FD fraction still on dialysis at time t, PY projected total haemodialysis patient years summed over the 5 years of the analysis period
  2. 1 From ERA-EDTA Registry: Annual Report 2014. Table B.6.7.a. Unadjusted 1-year survival (cohort 2008–2012): incident dialysis patients (from day 91).
  3. 2 Mortality rate of pts. inside range = overall mortality / ((% of patients outside range * RR) + % of patients in range)
  4. 3 Other loss to peritoneal dialysis or transplant assumed to be 5.3%
  5. 4 N0 assumed to be 303,517 based upon population estimates for countries participating in MONITOR-CKD5 [Table 3]
  6. 5 N1 assumed to be 66,597 based upon population estimates for countries participating in MONITOR-CKD5 [Table 3]
  7. 6 Patient-years gained if all 6 factors in target range is less than the sum of the years gained on the 6 individual factors since the modifiable practices are not mutually exclusive (i.e. patients can be outside target range on ≥1 factor)
  8. 7 Adjusted to 0.4830 of potential years gained if 100% brought within target (i.e. not .50, due to results of sensitivity analysis; personal communication with Arbor Research)