Table 3 Longitudinal associations of serum and dialysate electrolytes with QTc interval in 146 incident dialysis patients
Variables | Model 1 | Model 2 | Model 3 | |||
|---|---|---|---|---|---|---|
QTc difference (95% CI), ms | P | QTc difference (95% CI), ms | P | QTc difference (95% CI), ms | P | |
Serum measurements | ||||||
 Total calcium, per 1 mg/dl decrease | + 9.13 (0.65, 17.61) | 0.04 | + 8.89 (1.20, 16.58) | 0.02 | + 7.06 (− 0.59, 14.72) | 0.07 |
 Corrected calcium, per 1 mg/dl decrease | + 8.29 (−1.29, 17.88) | 0.09 | + 7.71 (− 0.91, 16.34) | 0.08 | + 5.74 (− 2.78, 14.26) | 0.19 |
 Ionized calciuma, per 0.1 mmol/l decrease | + 9.79 (3.17, 16.41) | 0.004 | + 10.18 (4.02, 16.33) | 0.001 | + 9.05 (3.28, 14.83) | 0.002 |
 Potassium, per 1 mEq/l decrease | + 9.08 (2.23, 15.94) | 0.01 | + 9.87 (3.12, 16.62) | 0.004 | + 9.43 (2.89, 15.98) | 0.01 |
 Magnesiuma, per 0.1 mEq/l decrease | + 0.84 (− 1.05, 2.74) | 0.38 | + 0.69 (− 1.26, 2.63) | 0.49 | + 0.32 (−1.60, 2.24) | 0.75 |
Dialysate measurements | ||||||
 Calcium | ||||||
  2.5 mEq/l | reference |  | reference |  | reference |  |
  < 2.5 mEq/l | + 3.18 (− 6.56, 12.91) | 0.52 | + 3.03 (− 6.07, 12.14) | 0.51 | + 4.00 (− 4.60, 12.60) | 0.36 |
 Potassium | ||||||
  2 mEq/l | reference |  | reference |  | reference |  |
  > 2 mEq/l | − 5.44 (− 21.22, 10.35) | 0.50 | −6.36 (− 21.05, 8.32) | 0.40 | − 5.58 (− 19.98, 8.82) | 0.45 |
Serum-to-dialysate gradients | ||||||
 Total calcium, per 1 mEq/l increase in difference | − 11.13 (− 23.59, 1.33) | 0.08 | −10.81 (− 22.38, 0.76) | 0.07 | −8.06 (− 18.88, 2.77) | 0.15 |
 Corrected calcium, per 1 mEq/l increase in difference | − 9.14 (− 22.83, 4.54) | 0.19 | − 8.48 (− 21.15, 4.19) | 0.2 | − 5.61 (− 17.34, 6.12) | 0.35 |