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Table 1 PICO characteristics

From: Clinical practice guideline monitoring children and young people with, or at risk of developing autosomal dominant polycystic kidney disease (ADPKD)

Population Intervention Comparison Outcome Study design
Children (< 18) with a confirmed diagnosis of ADPKD or at risk of ADPKD due to their family history Ultrasonography
Cranial imaging
Blood Pressure monitoring
Monitoring for albuminuria
Genetic counselling
Any intervention compared with any other or no intervention Mortality
Chronic Kidney Disease
Cardiovascular disease
Randomised controlled trials (RCT)
Non-randomised studies if adjusted for key confounders (age, health at baseline, co-morbidities).