Induction therapy with thymoglobulin or interleukin-2 receptor antagonist for Chinese recipients of living donor renal transplantation: a retrospective study

Table 3 Multivariate Cox regression analysis for the independent factors associated with clinically-suspected acute rejection or graft survival

Dependent variable	Covariate	Parameter estimate	Standard error	Risk ratio	P-value
Clinically-suspected acute rejection	Sex (male vs. female)	−0.284	0.685	0.753	0.678
	Age, years	−0.028	0.030	0.972	0.341
	HLA mismatch	0.204	0.588	1.227	0.728
	PRA (< 10% vs. > 10%)	0.632	0.923	1.882	0.493
	IL2-RA vs. rATG	−0.152	0.684	0.859	0.824
	Corticoids (no vs. yes)	−13.124	711.226	0.000 ^a	0.985
Graft survival	Sex (male vs. female)	1.213	1.290	3.362	0.347
	Age, years	0.038	0.059	1.039	0.519
	HLA mismatch	0.613	1.294	1.845	0.636
	PRA (< 10% vs. > 10%)	−11.464	1247.687	0.000 ^a	0.993
	IL2-RA vs. rATG	−12.260	780.889	0.000 ^a	0.987
	Corticoids (no vs. yes)	1.873	1.293	6.508	0.148

Multivariate Cox regression analysis was adjusted for patients’ age, sex, PRA score, HLA mismatch, and the use of corticoids
HLA = human leukocyte antigen; IL2-RA = interleukin-2 receptor agonist; PRA = panel reactive antibody; rATG = polyclonal rabbit antithymocyte globulin
^a, Due to the number of using corticoids was limited, some risk ratios were failed to be estimated and would be represented as 0.000 in SPSS output. However, the P-values still indicates there was no significant difference between IL2-RA and rATG groups

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