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Table 1 Changes in urinary protein, BUN and Scr in each group \( \overline{x}\kern0.5em \cdot \pm \kern0.5em s \), n = 10)

From: The role of podocyte damage in the etiology of ischemia-reperfusion acute kidney injury and post-injury fibrosis

 

Group

D8

D9

D10

D14

D28

UPE (mg/d)

Ctr

1.47 ± 0.11

1.43 ± 0.18

1.45 ± 0.16

1.43 ± 0.14

1.46 ± 0.21

Sham

1.42 ± 0.18

1.49 ± 0.16

1.40 ± 0.15

1.42 ± 0.15

1.48 ± 0.20

AKI 20

1.43 ± 0.15

1.53 ± 0.24

1.48 ± 0.17

1.50 ± 0.12

1.52 ± 0.15

AKI 30

1.46 ± 0.13

1.86 ± 0.38

1.97 ± 0.22

3.64 ± 1.12*

10.88 ± 2.44**

AKI 40

1.38 ± 0.20

3.47 ± 0.63*

2.52 ± 0.26*

1.54 ± 0.33

1.55 ± 0.18

BUN (mmol/L)

Ctr

11.41 ± 1.22

12.28 ± 1.01

10.99 ± 0.43

12.37 ± 1.29

10.93 ± 1.20

Sham

12.07 ± 1.31

10.92 ± 1.26

11.74 ± 0.55

12.49 ± 1.31

11.56 ± 1.47

AKI 20

11.89 ± 1.36

27.30 ± 2.32*

15.13 ± 1.11*

12.20 ± 1.24

11.12 ± 1.13

AKI 30

10.84 ± 1.47

28.48 ± 2.01*

17.36 ± 1.32*

25.45 ± 2.99*#

28.77 ± 1.23*#

AKI 40

12.35 ± 1.41

30.19 ± 2.62*#

25.27 ± 2.53*#

28.66 ± 1.78*#

37.48 ± 2.15*#Δ

Scr (umol/L)

Ctr

7.41 ± 0.82

7.20 ± 0.81

6.91 ± 0.63

7.03 ± 0.72

6.89 ± 0.75

Sham

7.03 ± 0.71

7.19 ± 0.98

7.17 ± 0.81

6.99 ± 0.76

7.11 ± 0.87

AKI 20

7.12 ± 0.80

16.39 ± 1.84*

13.88 ± 1.21*

7.78 ± 1.26

7.35 ± 1.18

AKI 30

7.81 ± 0.67

16.72 ± 1.56*

12.96 ± 1.43*

15.26 ± 1.29*#

22.34 ± 1.17*#

AKI 40

7.39 ± 0.88

16.58 ± 2.07*#

23.22 ± 2.38*#

28.97 ± 2.92*#Δ

28.04 ± 1.09*#Δ

  1. UPE, urinary protein excretion; BUN, blood urea nitrogen; Scr, serum creatinine. *P < 0.05 vs Ctr, **P < 0.01 vs Ctr, #P < 0.05 vs AKI 20, ΔP < 0.05 vs AKI 30