Fig. 3

Histological evaluation of the biopsy specimen at 3 months after transplantation. The cortex-to-medulla and global sclerosis-to-glomeruli ratios were 7/3 and 2/16, respectively, indicating chronic active antibody-mediated rejection, mild toxic tubulopathy, moderate arteriosclerosis, and mild arterior hyalinosis. Banff scores were i0, t0, g2, ptc0, v0, ci0, ct0, cg1b, cv0, ah1, and aah0. Peritubular capillaries exhibit focal C4d positivity by immunofluorescence (C4d2). Simian virus 40 was negative by immunohistochemistry using the streptavidin-biotin method. a Periodic acid–methenamine–silver stain, × 400; (b) periodic acid–Schiff stain, × 200; (c) Masson trichrome stain, × 40